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• W2800324871 endingPage "e0196040" @default.
• W2800324871 startingPage "e0196040" @default.
• W2800324871 abstract "Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid progenitor cells that are expanded in cancer and act as potent suppressors of the anti-tumor immune response. MDSCs consist of two major subsets, namely monocytic (M-) MDSCs and granulocytic (G-) MDSCs that differ with respect to their phenotype, morphology and mechanisms of suppression. Here, we cultured bone marrow cells with IL-6 and GM-CSF in vitro to generate a population of bone marrow MDSCs (BM-MDSCs) similar to G-MDSCs from tumor-bearing mice in regards to phenotype, morphology and suppressive-function. Through fluorescent labeling of these BM-MDSCs and optical imaging, we could visualize the recruitment and localization of BM-MDSCs in breast tumor-bearing mice in vivo. Furthermore, we were able to demonstrate that BM-MDSCs home to primary and metastatic breast tumors, but have no significant effect on tumor growth or progression. Ex vivo flow cytometry characterization of BM-MDSCs after adoptive transfer demonstrated both organ-and tumor-specific effects on their phenotype and differentiation, demonstrating the importance of the local microenvironment on MDSC fate and function. In this study, we have developed a method to generate, visualize and detect BM-MDSCs in vivo and ex vivo through optical imaging and flow cytometry, in order to understand the organ-specific changes rendered to MDSCs in breast cancer." @default.
• W2800324871 created "2018-05-17" @default.
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• W2800324871 date "2018-04-20" @default.
• W2800324871 modified "2023-10-03" @default.
• W2800324871 title "Tracking the fate of adoptively transferred myeloid-derived suppressor cells in the primary breast tumor microenvironment" @default.
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• W2800324871 doi "https://doi.org/10.1371/journal.pone.0196040" @default.
• W2800324871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5909918" @default.
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• W2800324871 hasPublicationYear "2018" @default.
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