Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800331244> ?p ?o ?g. }
- W2800331244 endingPage "156" @default.
- W2800331244 startingPage "113" @default.
- W2800331244 abstract "In the brain, fast inhibitory neurotransmission is mediated primarily by the ionotropic subtype of the gamma-aminobutyric acid (GABA) receptor subtype A (GABAAR). It is well established that the brain's GABAAR system mediates many aspects of neurobehavioral responses to alcohol (ethanol; EtOH). Accordingly, in both preclinical studies and some clinical scenarios, pharmacologically targeting the GABAAR system can alter neurobehavioral responses to acute and chronic EtOH consumption. However, many of the well-established interactions of EtOH and the GABAAR system have been identified at concentrations of EtOH ([EtOH]) that would only occur during abusive consumption of EtOH (≥40 mM), and there are still inadequate treatment options for prevention of or recovery from alcohol use disorder (AUD, including abuse and dependence). Accordingly, there is a general acknowledgement that more research is needed to identify and characterize: (1) neurobehavioral targets of lower [EtOH] and (2) associated brain structures that would involve such targets in a manner that may influence the development and maintenance of AUDs.Nearly 15 years ago it was discovered that the GABAAR system of the cerebellum is highly sensitive to EtOH, responding to concentrations as low as 10 mM (as would occur in the blood of a typical adult human after consuming 1-2 standard units of EtOH). This high sensitivity to EtOH, which likely mediates the well-known motor impairing effects of EtOH, combined with recent advances in our understanding of the role of the cerebellum in non-motor, cognitive/emotive/reward processes has renewed interest in this system in the specific context of AUD. In this chapter we will describe recent advances in our understanding of cerebellar processing, actions of EtOH on the cerebellar GABAAR system, and the potential relationship of such actions to the development of AUD. We will finish with speculation about how cerebellar specific GABAAR ligands might be effective pharmacological agents for treating aspects of AUD." @default.
- W2800331244 created "2018-05-17" @default.
- W2800331244 creator A5002707809 @default.
- W2800331244 creator A5055612248 @default.
- W2800331244 date "2018-01-01" @default.
- W2800331244 modified "2023-09-25" @default.
- W2800331244 title "The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder" @default.
- W2800331244 cites W105816717 @default.
- W2800331244 cites W1129520433 @default.
- W2800331244 cites W1501604912 @default.
- W2800331244 cites W1544755532 @default.
- W2800331244 cites W1550227666 @default.
- W2800331244 cites W1583427878 @default.
- W2800331244 cites W1588162263 @default.
- W2800331244 cites W1593697757 @default.
- W2800331244 cites W1600474674 @default.
- W2800331244 cites W1667569286 @default.
- W2800331244 cites W1701073181 @default.
- W2800331244 cites W1701778517 @default.
- W2800331244 cites W1788584426 @default.
- W2800331244 cites W1807514330 @default.
- W2800331244 cites W1825412704 @default.
- W2800331244 cites W182660780 @default.
- W2800331244 cites W1832744912 @default.
- W2800331244 cites W1871962537 @default.
- W2800331244 cites W1883557202 @default.
- W2800331244 cites W1895736150 @default.
- W2800331244 cites W1900369887 @default.
- W2800331244 cites W1912081453 @default.
- W2800331244 cites W1921693572 @default.
- W2800331244 cites W1926479678 @default.
- W2800331244 cites W1934227057 @default.
- W2800331244 cites W1964164372 @default.
- W2800331244 cites W1964917182 @default.
- W2800331244 cites W1965040767 @default.
- W2800331244 cites W1966725378 @default.
- W2800331244 cites W1967899444 @default.
- W2800331244 cites W1967930676 @default.
- W2800331244 cites W1969082619 @default.
- W2800331244 cites W1969593566 @default.
- W2800331244 cites W1971466075 @default.
- W2800331244 cites W1971627886 @default.
- W2800331244 cites W1971754950 @default.
- W2800331244 cites W1972058336 @default.
- W2800331244 cites W1972192149 @default.
- W2800331244 cites W1972697738 @default.
- W2800331244 cites W1975356290 @default.
- W2800331244 cites W1975706895 @default.
- W2800331244 cites W1976340258 @default.
- W2800331244 cites W1976562131 @default.
- W2800331244 cites W1977660693 @default.
- W2800331244 cites W1977712810 @default.
- W2800331244 cites W1978493649 @default.
- W2800331244 cites W1979007579 @default.
- W2800331244 cites W1979480286 @default.
- W2800331244 cites W1979778462 @default.
- W2800331244 cites W1980478962 @default.
- W2800331244 cites W1981020370 @default.
- W2800331244 cites W1981786093 @default.
- W2800331244 cites W1981964580 @default.
- W2800331244 cites W1983412442 @default.
- W2800331244 cites W1983893744 @default.
- W2800331244 cites W1985055240 @default.
- W2800331244 cites W1985244817 @default.
- W2800331244 cites W1985805006 @default.
- W2800331244 cites W1985874108 @default.
- W2800331244 cites W1986003234 @default.
- W2800331244 cites W1986217607 @default.
- W2800331244 cites W1988383440 @default.
- W2800331244 cites W1988628854 @default.
- W2800331244 cites W1989907680 @default.
- W2800331244 cites W1990324372 @default.
- W2800331244 cites W1991123877 @default.
- W2800331244 cites W1993663783 @default.
- W2800331244 cites W1994390109 @default.
- W2800331244 cites W1995246907 @default.
- W2800331244 cites W1995995989 @default.
- W2800331244 cites W1996088460 @default.
- W2800331244 cites W1996353639 @default.
- W2800331244 cites W1997707954 @default.
- W2800331244 cites W1998050348 @default.
- W2800331244 cites W1998333198 @default.
- W2800331244 cites W1998383469 @default.
- W2800331244 cites W1998419939 @default.
- W2800331244 cites W1999027102 @default.
- W2800331244 cites W1999130928 @default.
- W2800331244 cites W2000016530 @default.
- W2800331244 cites W2001350023 @default.
- W2800331244 cites W2001976844 @default.
- W2800331244 cites W2002081925 @default.
- W2800331244 cites W2004166962 @default.
- W2800331244 cites W2005379172 @default.
- W2800331244 cites W2005676838 @default.
- W2800331244 cites W2006667374 @default.
- W2800331244 cites W2007219297 @default.
- W2800331244 cites W2008434916 @default.
- W2800331244 cites W2008706955 @default.
- W2800331244 cites W2009369315 @default.