FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800338093> ?p ?o ?g. }

• W2800338093 endingPage "117" @default.
• W2800338093 startingPage "111" @default.
• W2800338093 abstract "<b><i>Background:</i></b> The Congenital Human Cytomegalovirus Infection Prevention (CHIP) study, a randomized, blinded, placebo-controlled trial, demonstrated that the efficacy of hyperimmune globulin (HIG) was not different from that of placebo regarding transmission of cytomegalovirus (CMV) from mothers to newborns. Our aim was to analyze histologically HIG effects on placentas collected for the CHIP study. <b><i>Materials and Methods:</i></b> Virological and histological analyses were performed on 40 placentas from transmitter and nontransmitter HIG-treated and untreated mothers by assessing the number of CMV-positive cells, tissue viral load, tissue damage, and compensatory mechanisms. <b><i>Results:</i></b> The HIG and placebo groups showed no significant differences in the number of CMV-positive cells (median number in 10 fields at 10 high-power fields: 2.5 vs. 2, <i>p</i> = 0.969) and viral load (median load: 5 copies/5 ng vs. 10.5 copies/5 ng, <i>p</i> = 0.874). Regarding histological examination, the scores of parameters related to tissue damage and hypoxic parenchymal compensation were higher in transmitters except for chorangiosis, with statistically significant differences observed for chronic villitis (<i>p</i> = 0.007), calcification (<i>p</i> = 0.011), and the total score of tissue damage (<i>p</i> &#x3c; 0.001). The HIG and placebo groups showed no significant differences for all tissue damage and compensation parameters and overall scores. <b><i>Discussion:</i></b> HIGs are not able to reduce placental viral load and histological damage, which was significantly associated only with infection." @default.
• W2800338093 created "2018-05-17" @default.
• W2800338093 creator A5004507388 @default.
• W2800338093 creator A5021418702 @default.
• W2800338093 creator A5038847535 @default.
• W2800338093 creator A5038891362 @default.
• W2800338093 creator A5049997254 @default.
• W2800338093 creator A5050955593 @default.
• W2800338093 creator A5053576163 @default.
• W2800338093 creator A5058298189 @default.
• W2800338093 creator A5066400165 @default.
• W2800338093 creator A5068277023 @default.
• W2800338093 creator A5070112832 @default.
• W2800338093 creator A5075939662 @default.
• W2800338093 creator A5086521294 @default.
• W2800338093 date "2018-04-23" @default.
• W2800338093 modified "2023-09-25" @default.
• W2800338093 title "Histological Analysis of Term Placentas from Hyperimmune Globulin-Treated and Untreated Mothers with Primary Cytomegalovirus Infection" @default.
• W2800338093 cites W1534726407 @default.
• W2800338093 cites W1970185637 @default.
• W2800338093 cites W1974769266 @default.
• W2800338093 cites W1995900761 @default.
• W2800338093 cites W2035930608 @default.
• W2800338093 cites W2042344849 @default.
• W2800338093 cites W2067092950 @default.
• W2800338093 cites W2069478486 @default.
• W2800338093 cites W2076933260 @default.
• W2800338093 cites W2100351408 @default.
• W2800338093 cites W2102639562 @default.
• W2800338093 cites W2121020022 @default.
• W2800338093 cites W2125041033 @default.
• W2800338093 cites W2133963802 @default.
• W2800338093 cites W2141204682 @default.
• W2800338093 cites W2162778062 @default.
• W2800338093 cites W2165012523 @default.
• W2800338093 cites W2394753193 @default.
• W2800338093 cites W2480985761 @default.
• W2800338093 cites W2489894000 @default.
• W2800338093 cites W2509248929 @default.
• W2800338093 cites W2570040139 @default.
• W2800338093 doi "https://doi.org/10.1159/000487302" @default.
• W2800338093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29684915" @default.
• W2800338093 hasPublicationYear "2018" @default.
• W2800338093 type Work @default.
• W2800338093 sameAs 2800338093 @default.
• W2800338093 citedByCount "14" @default.
• W2800338093 countsByYear W28003380932019 @default.
• W2800338093 countsByYear W28003380932020 @default.
• W2800338093 countsByYear W28003380932021 @default.
• W2800338093 countsByYear W28003380932022 @default.
• W2800338093 crossrefType "journal-article" @default.
• W2800338093 hasAuthorship W2800338093A5004507388 @default.
• W2800338093 hasAuthorship W2800338093A5021418702 @default.
• W2800338093 hasAuthorship W2800338093A5038847535 @default.
• W2800338093 hasAuthorship W2800338093A5038891362 @default.
• W2800338093 hasAuthorship W2800338093A5049997254 @default.
• W2800338093 hasAuthorship W2800338093A5050955593 @default.
• W2800338093 hasAuthorship W2800338093A5053576163 @default.
• W2800338093 hasAuthorship W2800338093A5058298189 @default.
• W2800338093 hasAuthorship W2800338093A5066400165 @default.
• W2800338093 hasAuthorship W2800338093A5068277023 @default.
• W2800338093 hasAuthorship W2800338093A5070112832 @default.
• W2800338093 hasAuthorship W2800338093A5075939662 @default.
• W2800338093 hasAuthorship W2800338093A5086521294 @default.
• W2800338093 hasConcept C126322002 @default.
• W2800338093 hasConcept C142462285 @default.
• W2800338093 hasConcept C142724271 @default.
• W2800338093 hasConcept C203014093 @default.
• W2800338093 hasConcept C2522874641 @default.
• W2800338093 hasConcept C2776409557 @default.
• W2800338093 hasConcept C2777732132 @default.
• W2800338093 hasConcept C2779820661 @default.
• W2800338093 hasConcept C2780727368 @default.
• W2800338093 hasConcept C57742111 @default.
• W2800338093 hasConcept C71924100 @default.
• W2800338093 hasConcept C90924648 @default.
• W2800338093 hasConceptScore W2800338093C126322002 @default.
• W2800338093 hasConceptScore W2800338093C142462285 @default.
• W2800338093 hasConceptScore W2800338093C142724271 @default.
• W2800338093 hasConceptScore W2800338093C203014093 @default.
• W2800338093 hasConceptScore W2800338093C2522874641 @default.
• W2800338093 hasConceptScore W2800338093C2776409557 @default.
• W2800338093 hasConceptScore W2800338093C2777732132 @default.
• W2800338093 hasConceptScore W2800338093C2779820661 @default.
• W2800338093 hasConceptScore W2800338093C2780727368 @default.
• W2800338093 hasConceptScore W2800338093C57742111 @default.
• W2800338093 hasConceptScore W2800338093C71924100 @default.
• W2800338093 hasConceptScore W2800338093C90924648 @default.
• W2800338093 hasIssue "2" @default.
• W2800338093 hasLocation W28003380931 @default.
• W2800338093 hasLocation W28003380932 @default.
• W2800338093 hasOpenAccess W2800338093 @default.
• W2800338093 hasPrimaryLocation W28003380931 @default.
• W2800338093 hasRelatedWork W1846771597 @default.
• W2800338093 hasRelatedWork W1997462663 @default.
• W2800338093 hasRelatedWork W2042750307 @default.
• W2800338093 hasRelatedWork W2140647949 @default.
• W2800338093 hasRelatedWork W2153824193 @default.

• next