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• W2800366807 abstract "Hair cell (HC) loss is irreversible because only very limited HC regeneration has been observed in the adult mammalian cochlea. Wnt/β-catenin signaling regulates prosensory cell proliferation and differentiation during cochlear development, and Wnt activation promotes the proliferation of Lgr5+ cochlear HC progenitors in newborn mice. Similar to Lgr5, Lgr6 is also a Wnt downstream target gene. Lgr6 is reported to be present in adult stem cells in the skin, nail, tongue, lung, and mammary gland, and this protein is very important for adult stem cell maintenance in rapidly proliferating organs. Our previous studies showed that Lgr6+ cells are a subpopulation of Lgr5+ progenitor cells and that both Lgr6+ and Lgr5+ progenitors can generate Myosin7a+ HCs in vitro. Thus we hypothesized that Lgr6+ cells are an enriched population of cochlear progenitor cells. However, the detailed distinctions between the Lgr5+ and Lgr6+ progenitors are unclear. Here, we systematically compared the proliferation, HC differentiation, and detailed transcriptome expression profiles of these two progenitor populations. We found that the same number of isolated Lgr6+ progenitors generated significantly more Myosin7a+ HCs compared to Lgr5+ progenitors; however, Lgr5+ progenitors formed more epithelial colonies and more spheres than Lgr6+ progenitors in vitro. Using RNA-Seq, we compared the transcriptome differences between Lgr5+ and Lgr6+ progenitors and identified a list of significantly differential expressed genes that might regulate the proliferation and differentiation of these HC progenitors, including 4 cell cycle genes, 9 cell signaling pathway genes, and 54 transcription factors. In conclusion, we demonstrate that Lgr6+ progenitors are an enriched population of inner ear progenitors that generate more HCs compared to Lgr5+ progenitors in the newborn mouse cochlea, and the our research provides a series of genes that might regulate the proliferation of progenitors and HC generation." @default.
• W2800366807 created "2018-05-17" @default.
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• W2800366807 date "2018-05-14" @default.
• W2800366807 modified "2023-10-15" @default.
• W2800366807 title "Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea" @default.
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• W2800366807 cites W1519680742 @default.
• W2800366807 cites W1531041690 @default.
• W2800366807 cites W1607933147 @default.
• W2800366807 cites W1825744067 @default.
• W2800366807 cites W1930773806 @default.
• W2800366807 cites W1966248136 @default.
• W2800366807 cites W1971041510 @default.
• W2800366807 cites W1971757408 @default.
• W2800366807 cites W1972763237 @default.
• W2800366807 cites W1977512185 @default.
• W2800366807 cites W1982603620 @default.
• W2800366807 cites W1986127962 @default.
• W2800366807 cites W1992857468 @default.
• W2800366807 cites W1995048201 @default.
• W2800366807 cites W2000387440 @default.
• W2800366807 cites W2011540182 @default.
• W2800366807 cites W2012694604 @default.
• W2800366807 cites W2013935392 @default.
• W2800366807 cites W2016551584 @default.
• W2800366807 cites W2018448892 @default.
• W2800366807 cites W2020975008 @default.
• W2800366807 cites W2021689495 @default.
• W2800366807 cites W2023914268 @default.
• W2800366807 cites W2024299195 @default.
• W2800366807 cites W2026120980 @default.
• W2800366807 cites W2027705175 @default.
• W2800366807 cites W2028916500 @default.
• W2800366807 cites W2031735932 @default.
• W2800366807 cites W2032005913 @default.
• W2800366807 cites W2034193769 @default.
• W2800366807 cites W2036475825 @default.
• W2800366807 cites W2038440214 @default.
• W2800366807 cites W2044947020 @default.
• W2800366807 cites W2045146348 @default.
• W2800366807 cites W2045766973 @default.
• W2800366807 cites W2051109455 @default.
• W2800366807 cites W2059117477 @default.
• W2800366807 cites W2064128449 @default.
• W2800366807 cites W2065181562 @default.
• W2800366807 cites W2066054477 @default.
• W2800366807 cites W2067406512 @default.
• W2800366807 cites W2069409989 @default.
• W2800366807 cites W2082745903 @default.
• W2800366807 cites W2084649822 @default.
• W2800366807 cites W2085550383 @default.
• W2800366807 cites W2092612913 @default.
• W2800366807 cites W2097387056 @default.
• W2800366807 cites W2099434983 @default.
• W2800366807 cites W2100706309 @default.
• W2800366807 cites W2121945159 @default.
• W2800366807 cites W2124045501 @default.
• W2800366807 cites W2129384667 @default.
• W2800366807 cites W2145406100 @default.
• W2800366807 cites W2147664526 @default.
• W2800366807 cites W2150411258 @default.
• W2800366807 cites W2152953538 @default.
• W2800366807 cites W2153027227 @default.
• W2800366807 cites W2156310646 @default.
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• W2800366807 cites W2172326429 @default.
• W2800366807 cites W2174993055 @default.
• W2800366807 cites W2331733158 @default.
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• W2800366807 cites W2544022674 @default.
• W2800366807 cites W2566451828 @default.
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• W2800366807 doi "https://doi.org/10.3389/fnmol.2018.00147" @default.
• W2800366807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5961437" @default.
• W2800366807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29867341" @default.
• W2800366807 hasPublicationYear "2018" @default.
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