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- W2800380700 endingPage "1004" @default.
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- W2800380700 abstract "Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS). First, we review individual immune loci identified in secondary analyses of GWAS, which implicate over 30 genes expressed in both immune and brain cells. The function of the proteins encoded by these immune candidates highlight the role of the complement system, along with regulation of apoptosis in both immune and neuronal cells. Next, we review hypothesis-free pathway analyses which have so far been inconclusive with respect to identifying immune pathways involved in schizophrenia. Finally, we explore the genetic overlap between schizophrenia and immune-mediated diseases. Although there have been some inconsistencies across studies, genome-wide pleiotropy has been reported between schizophrenia and Crohn's disease, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and ulcerative colitis. Overall, there are multiple lines of evidence supporting the role of immune genes in schizophrenia. Current evidence suggests that specific immune pathways are involved-likely those with dual functions in the central nervous system. Future studies focused on further elucidating the relevant pathways hold the potential to identify novel biomarkers and therapeutic targets for schizophrenia." @default.
- W2800380700 created "2018-05-17" @default.
- W2800380700 creator A5060455962 @default.
- W2800380700 date "2018-04-26" @default.
- W2800380700 modified "2023-10-11" @default.
- W2800380700 title "The Emerging Immunogenetic Architecture of Schizophrenia" @default.
- W2800380700 cites W1014257459 @default.
- W2800380700 cites W1213234716 @default.
- W2800380700 cites W1580177128 @default.
- W2800380700 cites W1821495885 @default.
- W2800380700 cites W1844405070 @default.
- W2800380700 cites W1872612762 @default.
- W2800380700 cites W1964007647 @default.
- W2800380700 cites W1964322942 @default.
- W2800380700 cites W1969833165 @default.
- W2800380700 cites W1971514078 @default.
- W2800380700 cites W1975558622 @default.
- W2800380700 cites W1979856142 @default.
- W2800380700 cites W1980725116 @default.
- W2800380700 cites W1980789245 @default.
- W2800380700 cites W1988404229 @default.
- W2800380700 cites W1989590412 @default.
- W2800380700 cites W1989879415 @default.
- W2800380700 cites W1993588417 @default.
- W2800380700 cites W1996299724 @default.
- W2800380700 cites W1998422450 @default.
- W2800380700 cites W2002024279 @default.
- W2800380700 cites W2003506028 @default.
- W2800380700 cites W2009998811 @default.
- W2800380700 cites W2010160850 @default.
- W2800380700 cites W2012034410 @default.
- W2800380700 cites W2020634566 @default.
- W2800380700 cites W2023962370 @default.
- W2800380700 cites W2024108088 @default.
- W2800380700 cites W2024406337 @default.
- W2800380700 cites W2028546773 @default.
- W2800380700 cites W2032714982 @default.
- W2800380700 cites W2033617297 @default.
- W2800380700 cites W2036569944 @default.
- W2800380700 cites W2037890112 @default.
- W2800380700 cites W2038296024 @default.
- W2800380700 cites W2040547343 @default.
- W2800380700 cites W2042755650 @default.
- W2800380700 cites W2044833878 @default.
- W2800380700 cites W2045227722 @default.
- W2800380700 cites W2045761141 @default.
- W2800380700 cites W2046434400 @default.
- W2800380700 cites W2048011602 @default.
- W2800380700 cites W2051158121 @default.
- W2800380700 cites W2054344444 @default.
- W2800380700 cites W2055655674 @default.
- W2800380700 cites W2064979740 @default.
- W2800380700 cites W2076040334 @default.
- W2800380700 cites W2094520476 @default.
- W2800380700 cites W2096173332 @default.
- W2800380700 cites W2098143048 @default.
- W2800380700 cites W2098597355 @default.
- W2800380700 cites W2099647122 @default.
- W2800380700 cites W2100185570 @default.
- W2800380700 cites W2101357408 @default.
- W2800380700 cites W2102889851 @default.
- W2800380700 cites W2104549677 @default.
- W2800380700 cites W2106506181 @default.
- W2800380700 cites W2106779017 @default.
- W2800380700 cites W2109052112 @default.
- W2800380700 cites W2110269506 @default.
- W2800380700 cites W2110729320 @default.
- W2800380700 cites W2112409097 @default.
- W2800380700 cites W2113628570 @default.
- W2800380700 cites W2115783720 @default.
- W2800380700 cites W2115807273 @default.
- W2800380700 cites W2116107710 @default.
- W2800380700 cites W2118561577 @default.
- W2800380700 cites W2121323687 @default.
- W2800380700 cites W2121637331 @default.
- W2800380700 cites W2125238755 @default.
- W2800380700 cites W2126824241 @default.
- W2800380700 cites W2128376310 @default.
- W2800380700 cites W2129031013 @default.
- W2800380700 cites W2129710299 @default.
- W2800380700 cites W2134783591 @default.
- W2800380700 cites W2137493625 @default.
- W2800380700 cites W2139852368 @default.
- W2800380700 cites W2161527093 @default.
- W2800380700 cites W2163170565 @default.
- W2800380700 cites W2163749231 @default.
- W2800380700 cites W2164392039 @default.
- W2800380700 cites W2195783463 @default.
- W2800380700 cites W2244701831 @default.
- W2800380700 cites W2255138985 @default.
- W2800380700 cites W2265750521 @default.
- W2800380700 cites W2339196082 @default.
- W2800380700 cites W2343055661 @default.
- W2800380700 cites W2343912748 @default.
- W2800380700 cites W2408773464 @default.
- W2800380700 cites W2532117501 @default.
- W2800380700 cites W2559028527 @default.
- W2800380700 cites W2587178939 @default.