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- W2800382802 abstract "Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease in adults characterized by the deposition of extracellular plaques of β-amyloid protein (Aβ), intracellular neurofibrillary tangles (NFTs), synaptic loss and neuronal apoptosis. AD has a strong and complex genetic component that involving into multiple genes. With recent advances in whole-exome sequencing (WES) and whole-genome sequencing (WGS) technology, UNC5C was identified to have association with AD. Emerging studies on cell and animal models identified that aberrant UNC5C may contribute to AD by activating death-associated protein kinase 1 (DAPK1) which is a new component involved in AD pathogenesis with an extensive involvement in aberrant tau, Aβ and neuronal apoptosis/autophagy. In this review, we briefly summarize the biochemical properties, genetics, epigenetics, and the speculative role of UNC5C in AD. We hope our review would bring comprehensive understandings of AD pathogenesis and provide new therapeutic targets for AD." @default.
- W2800382802 created "2018-05-17" @default.
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- W2800382802 date "2018-05-01" @default.
- W2800382802 modified "2023-10-10" @default.
- W2800382802 title "The role of UNC5C in Alzheimer’s disease" @default.
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- W2800382802 cites W1783805685 @default.
- W2800382802 cites W1897859562 @default.
- W2800382802 cites W1906218212 @default.
- W2800382802 cites W1919284756 @default.
- W2800382802 cites W1958103180 @default.
- W2800382802 cites W1964111853 @default.
- W2800382802 cites W1974514312 @default.
- W2800382802 cites W1983693972 @default.
- W2800382802 cites W1985025450 @default.
- W2800382802 cites W1985375719 @default.
- W2800382802 cites W1991560220 @default.
- W2800382802 cites W2001224052 @default.
- W2800382802 cites W2012543502 @default.
- W2800382802 cites W2015682243 @default.
- W2800382802 cites W2018258194 @default.
- W2800382802 cites W2026205355 @default.
- W2800382802 cites W2026369298 @default.
- W2800382802 cites W2031702481 @default.
- W2800382802 cites W2035102492 @default.
- W2800382802 cites W2036210716 @default.
- W2800382802 cites W2037698517 @default.
- W2800382802 cites W2039363263 @default.
- W2800382802 cites W2041521913 @default.
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- W2800382802 cites W2107094473 @default.
- W2800382802 cites W2107336286 @default.
- W2800382802 cites W2117050355 @default.
- W2800382802 cites W2118867129 @default.
- W2800382802 cites W2129085204 @default.
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- W2800382802 cites W2222383395 @default.
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- W2800382802 doi "https://doi.org/10.21037/atm.2018.04.43" @default.
- W2800382802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5994511" @default.
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- W2800382802 hasPublicationYear "2018" @default.
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