Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800388515> ?p ?o ?g. }
- W2800388515 endingPage "10" @default.
- W2800388515 startingPage "1" @default.
- W2800388515 abstract "The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca2+ influx and electrophysiological recordings. To determine the inhibitory mechanisms, additional functional tests and molecular docking experiments are performed. The results established that TCAs (a) inhibit Ca2+ influx in GH3-α7 cells with the following potency (IC50 in μM) rank: amitriptyline (2.7 ± 0.3) > doxepin (5.9 ± 1.1) ∼ imipramine (6.6 ± 1.0). Interestingly, imipramine inhibits hippocampal α7* AChRs (42.2 ± 8.5 μM) in a noncompetitive and voltage-dependent manner, whereas it inhibits α9α10 AChRs (0.53 ± 0.05 μM) in a competitive and voltage-independent manner, and (b) inhibit [3H]imipramine binding to resting α7 AChRs with the following affinity rank (IC50 in μM): imipramine (1.6 ± 0.2) > amitriptyline (2.4 ± 0.3) > doxepin (4.9 ± 0.6), whereas imipramine’s affinity was no significantly different to that for the desensitized state. The molecular docking and functional results support the notion that imipramine noncompetitively inhibits α7 AChRs by interacting with two overlapping luminal sites, whereas it competitively inhibits α9α10 AChRs by interacting with the orthosteric sites. Collectively our data indicate that TCAs inhibit α7, α9α10, and hippocampal α7* AChRs at clinically relevant concentrations and by different mechanisms of action." @default.
- W2800388515 created "2018-05-17" @default.
- W2800388515 creator A5008550312 @default.
- W2800388515 creator A5044018983 @default.
- W2800388515 creator A5053148889 @default.
- W2800388515 creator A5053686535 @default.
- W2800388515 creator A5060160922 @default.
- W2800388515 creator A5070890303 @default.
- W2800388515 creator A5072375700 @default.
- W2800388515 creator A5091877247 @default.
- W2800388515 date "2018-07-01" @default.
- W2800388515 modified "2023-10-12" @default.
- W2800388515 title "Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms" @default.
- W2800388515 cites W1166424394 @default.
- W2800388515 cites W1666054347 @default.
- W2800388515 cites W1975263142 @default.
- W2800388515 cites W1982429100 @default.
- W2800388515 cites W1990627326 @default.
- W2800388515 cites W1996065721 @default.
- W2800388515 cites W2009320019 @default.
- W2800388515 cites W2010864673 @default.
- W2800388515 cites W2012482374 @default.
- W2800388515 cites W2015211105 @default.
- W2800388515 cites W2018361785 @default.
- W2800388515 cites W2030405347 @default.
- W2800388515 cites W2049470274 @default.
- W2800388515 cites W2053821073 @default.
- W2800388515 cites W2055335693 @default.
- W2800388515 cites W2061166243 @default.
- W2800388515 cites W2074631079 @default.
- W2800388515 cites W2076367337 @default.
- W2800388515 cites W2077857371 @default.
- W2800388515 cites W2082242341 @default.
- W2800388515 cites W2086619790 @default.
- W2800388515 cites W2094065556 @default.
- W2800388515 cites W2094508033 @default.
- W2800388515 cites W2107208446 @default.
- W2800388515 cites W2138961317 @default.
- W2800388515 cites W2147285542 @default.
- W2800388515 cites W2155508698 @default.
- W2800388515 cites W2163994482 @default.
- W2800388515 cites W2290437216 @default.
- W2800388515 cites W2290662239 @default.
- W2800388515 cites W2301272550 @default.
- W2800388515 cites W2326124703 @default.
- W2800388515 cites W2397409999 @default.
- W2800388515 cites W2516412545 @default.
- W2800388515 cites W2524130802 @default.
- W2800388515 cites W2589359833 @default.
- W2800388515 cites W2619865027 @default.
- W2800388515 cites W2755803420 @default.
- W2800388515 cites W2765587492 @default.
- W2800388515 doi "https://doi.org/10.1016/j.biocel.2018.04.017" @default.
- W2800388515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29704625" @default.
- W2800388515 hasPublicationYear "2018" @default.
- W2800388515 type Work @default.
- W2800388515 sameAs 2800388515 @default.
- W2800388515 citedByCount "8" @default.
- W2800388515 countsByYear W28003885152018 @default.
- W2800388515 countsByYear W28003885152019 @default.
- W2800388515 countsByYear W28003885152021 @default.
- W2800388515 countsByYear W28003885152022 @default.
- W2800388515 countsByYear W28003885152023 @default.
- W2800388515 crossrefType "journal-article" @default.
- W2800388515 hasAuthorship W2800388515A5008550312 @default.
- W2800388515 hasAuthorship W2800388515A5044018983 @default.
- W2800388515 hasAuthorship W2800388515A5053148889 @default.
- W2800388515 hasAuthorship W2800388515A5053686535 @default.
- W2800388515 hasAuthorship W2800388515A5060160922 @default.
- W2800388515 hasAuthorship W2800388515A5070890303 @default.
- W2800388515 hasAuthorship W2800388515A5072375700 @default.
- W2800388515 hasAuthorship W2800388515A5091877247 @default.
- W2800388515 hasConcept C12554922 @default.
- W2800388515 hasConcept C142724271 @default.
- W2800388515 hasConcept C148762608 @default.
- W2800388515 hasConcept C169760540 @default.
- W2800388515 hasConcept C170493617 @default.
- W2800388515 hasConcept C185592680 @default.
- W2800388515 hasConcept C188987157 @default.
- W2800388515 hasConcept C204787440 @default.
- W2800388515 hasConcept C2777747321 @default.
- W2800388515 hasConcept C2779145073 @default.
- W2800388515 hasConcept C2780216858 @default.
- W2800388515 hasConcept C2781081902 @default.
- W2800388515 hasConcept C55493867 @default.
- W2800388515 hasConcept C71240020 @default.
- W2800388515 hasConcept C71924100 @default.
- W2800388515 hasConcept C80161118 @default.
- W2800388515 hasConcept C86803240 @default.
- W2800388515 hasConcept C98274493 @default.
- W2800388515 hasConceptScore W2800388515C12554922 @default.
- W2800388515 hasConceptScore W2800388515C142724271 @default.
- W2800388515 hasConceptScore W2800388515C148762608 @default.
- W2800388515 hasConceptScore W2800388515C169760540 @default.
- W2800388515 hasConceptScore W2800388515C170493617 @default.
- W2800388515 hasConceptScore W2800388515C185592680 @default.
- W2800388515 hasConceptScore W2800388515C188987157 @default.
- W2800388515 hasConceptScore W2800388515C204787440 @default.