Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800402034> ?p ?o ?g. }
- W2800402034 endingPage "1268" @default.
- W2800402034 startingPage "1258" @default.
- W2800402034 abstract "Persistent organochlorine pollutants (POPs) have shown to be involved in the atherosclerotic process and to cause endothelial cell dysfunction. To assess longitudinally whether plasma concentrations of different POPs were associated with blood pressure and risk of hypertension in middle-aged women and men. Study subjects were 850 participants in the VIP (Västerbotten Intervention Programme) with 2 blood samples and blood pressure measurements, 10 years apart, during 1990 to 2003 (baseline) and during 2000 to 2013 (follow-up). Dioxin-like and nondioxin-like polychlorinated biphenyls (DL-PCBs, NDL-PCBs) and p,p′-dichlorodiphenyldichloroethylene (DDE) were measured. Associations were assessed using generalized estimating equations. At baseline sampling 49% and at follow-up 64% had hypertension. DL-PCBs and DDE, but not NDL-PCBs or hexachlorobenzene, were associated with hypertension. Only the association for DL-PCBs remained statistically significant after lipid-standardization and adjustment for body mass index and total serum lipids. The multivariable-adjusted odds ratio of hypertension based on repeated measurements were 1.52 (95% confidence interval, 1.08–2.13) for DL-PCBs (third versus first tertile of lipid-standardized POPs). In stratified adjusted analyses, odds ratio for those born after 1950 increased to 3.99 (95% confidence interval, 2.15–7.43), whereas no association was observed among those born earlier. Based on repeated measurements, the accumulated exposure to DL-PCBs and DDE, although less clear for the latter, may disrupt the normal blood pressure levels and increase the odds of hypertension. Moreover, individuals experiencing early-life POP exposure may be at elevated risk of vascular POP effects." @default.
- W2800402034 created "2018-05-17" @default.
- W2800402034 creator A5023243905 @default.
- W2800402034 creator A5026704231 @default.
- W2800402034 creator A5038869039 @default.
- W2800402034 creator A5039844258 @default.
- W2800402034 creator A5046430598 @default.
- W2800402034 creator A5055284074 @default.
- W2800402034 creator A5057049990 @default.
- W2800402034 creator A5084744442 @default.
- W2800402034 date "2018-06-01" @default.
- W2800402034 modified "2023-10-16" @default.
- W2800402034 title "Persistent Organochlorine Pollutants in Plasma, Blood Pressure, and Hypertension in a Longitudinal Study" @default.
- W2800402034 cites W1275357281 @default.
- W2800402034 cites W1829196803 @default.
- W2800402034 cites W1907953089 @default.
- W2800402034 cites W1964607854 @default.
- W2800402034 cites W1966912126 @default.
- W2800402034 cites W1968680997 @default.
- W2800402034 cites W1969253172 @default.
- W2800402034 cites W1974967017 @default.
- W2800402034 cites W1975141079 @default.
- W2800402034 cites W1988164132 @default.
- W2800402034 cites W1994370086 @default.
- W2800402034 cites W1996367595 @default.
- W2800402034 cites W2001947552 @default.
- W2800402034 cites W2002082264 @default.
- W2800402034 cites W2002433574 @default.
- W2800402034 cites W2010575486 @default.
- W2800402034 cites W2013518305 @default.
- W2800402034 cites W2016442530 @default.
- W2800402034 cites W2020393862 @default.
- W2800402034 cites W2027127325 @default.
- W2800402034 cites W2031139047 @default.
- W2800402034 cites W2031630844 @default.
- W2800402034 cites W2034162108 @default.
- W2800402034 cites W2035506483 @default.
- W2800402034 cites W2035521809 @default.
- W2800402034 cites W2036352541 @default.
- W2800402034 cites W2043928821 @default.
- W2800402034 cites W2046201264 @default.
- W2800402034 cites W2046669879 @default.
- W2800402034 cites W2050461948 @default.
- W2800402034 cites W2062098773 @default.
- W2800402034 cites W2066377713 @default.
- W2800402034 cites W2067844759 @default.
- W2800402034 cites W2070072191 @default.
- W2800402034 cites W2074314782 @default.
- W2800402034 cites W2077948755 @default.
- W2800402034 cites W2079034109 @default.
- W2800402034 cites W2079765398 @default.
- W2800402034 cites W2080353255 @default.
- W2800402034 cites W2082197273 @default.
- W2800402034 cites W2082336058 @default.
- W2800402034 cites W2087545338 @default.
- W2800402034 cites W2097037258 @default.
- W2800402034 cites W2128037741 @default.
- W2800402034 cites W2136138120 @default.
- W2800402034 cites W2138185074 @default.
- W2800402034 cites W2142935305 @default.
- W2800402034 cites W2149097469 @default.
- W2800402034 cites W2153856142 @default.
- W2800402034 cites W2165839735 @default.
- W2800402034 cites W224049 @default.
- W2800402034 cites W2312574013 @default.
- W2800402034 cites W2344335473 @default.
- W2800402034 cites W2418704707 @default.
- W2800402034 cites W2492592129 @default.
- W2800402034 cites W2503385401 @default.
- W2800402034 cites W2512543235 @default.
- W2800402034 cites W2535762306 @default.
- W2800402034 cites W2572331255 @default.
- W2800402034 cites W2606750868 @default.
- W2800402034 doi "https://doi.org/10.1161/hypertensionaha.117.10691" @default.
- W2800402034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5959216" @default.
- W2800402034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29712742" @default.
- W2800402034 hasPublicationYear "2018" @default.
- W2800402034 type Work @default.
- W2800402034 sameAs 2800402034 @default.
- W2800402034 citedByCount "30" @default.
- W2800402034 countsByYear W28004020342018 @default.
- W2800402034 countsByYear W28004020342019 @default.
- W2800402034 countsByYear W28004020342020 @default.
- W2800402034 countsByYear W28004020342021 @default.
- W2800402034 countsByYear W28004020342022 @default.
- W2800402034 countsByYear W28004020342023 @default.
- W2800402034 crossrefType "journal-article" @default.
- W2800402034 hasAuthorship W2800402034A5023243905 @default.
- W2800402034 hasAuthorship W2800402034A5026704231 @default.
- W2800402034 hasAuthorship W2800402034A5038869039 @default.
- W2800402034 hasAuthorship W2800402034A5039844258 @default.
- W2800402034 hasAuthorship W2800402034A5046430598 @default.
- W2800402034 hasAuthorship W2800402034A5055284074 @default.
- W2800402034 hasAuthorship W2800402034A5057049990 @default.
- W2800402034 hasAuthorship W2800402034A5084744442 @default.
- W2800402034 hasBestOaLocation W28004020341 @default.
- W2800402034 hasConcept C126322002 @default.
- W2800402034 hasConcept C134018914 @default.