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- W2800413269 abstract "Skin-related human polyomaviruses include Merkel cell polyomavirus (MCPyV), Human polyomavirus 6 (HPyV6), Human polyomavirus 7 (HPyV7), and Trichodysplasia spinulosa polyomavirus (TSPyV). The p38-MAPK/MSK pathway mediates phosphorylation of histone H3 and has been found to be dysregulated in a variety of pathologies, including Merkel Cell Carcinoma. Herein, we aimed to study the stress-related p38-MAPK pathway, including downstream H3 phosphorylation, in cells expressing polyomavirus small T (sT) antigen. Distinct HEK293 cell lines expressing sT antigens for MCPyV, HPyV6, HPyV7, and MCPyV were developed using respective subcloned sT coding genes, and activation of the p38-MAPK/MSK/H3 axis was determined using phospho-site specific antibodies in Western Blot analyses. We observed p38 and MSK to be activated in MCPyV and HPyV7 sT antigen expressing cells. Furthermore, H3 phosphorylation was detected in TSPyV, HPyV7, and MCPyV sT antigen expressing cells, but not in HPyV6 sT producing cells. Overall, this study demonstrates that the p38-MAPK/MSK/H3 axis is activated in vitro by MCPyV and HPyV7 sT antigens and that TSPyV sT is further associated with H3 phosphorylation. These findings add new information about the differential molecular signaling characteristics associated with polyomavirus sT antigens and may be useful for developing novel therapeutic interventions for related diseases." @default.
- W2800413269 created "2018-05-17" @default.
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- W2800413269 date "2018-05-01" @default.
- W2800413269 modified "2023-10-18" @default.
- W2800413269 title "847 Modulation of the p38-MAPK/MSK/Histone H3 axis by select cutaneous polyomavirus small T antigens" @default.
- W2800413269 doi "https://doi.org/10.1016/j.jid.2018.03.858" @default.
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