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- W2800440086 abstract "Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration." @default.
- W2800440086 created "2018-05-17" @default.
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- W2800440086 date "2018-05-01" @default.
- W2800440086 modified "2023-10-18" @default.
- W2800440086 title "Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging" @default.
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- W2800440086 doi "https://doi.org/10.1016/j.stem.2018.04.001" @default.
- W2800440086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5940005" @default.
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