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- W2800440897 abstract "Aim: The aim of the present study was to develop polyethyleneimine-simvastatin acid nanoparticles (PEI-SVA-NPs) loaded conducting scaffolds as drug delivery for osteogenesis in bone tissue regeneration. Materials and Methods: The PEI-SVA-NPs were prepared by nanoprecipitation by mixing PEI and SVA solutions. The freeze-dried NPs were loaded at 0.1, 0.5, and 1 mg onto the conducting scaffolds comprising chitosan grafted polyaniline/chitosan-gelatin matrices for drug release, biocompatibility, and alkaline phosphatase (ALP) activity studies. Results and Discussion: The PEI-SVA-NPs loaded conducting matrices exhibited slower drug release profiles compared with the free drug ones. Biocompatibility of the matrices was excellent on MC3T3-E1 cells. The PEI-SVA-NPs loading showed higher efficacy on promotion of osteogenesis than the free drug loading. Increasing ALP activity was found with increasing the PEI-SVA-NPs loading. Conclusion: The PEI-SVA-NPs loaded conducting matrices exhibited controlled release, biocompatibility, and osteogenic properties. The results strongly support the possibility of these matrices to be useful for bone tissue engineering application." @default.
- W2800440897 created "2018-05-17" @default.
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- W2800440897 date "2018-03-01" @default.
- W2800440897 modified "2023-09-26" @default.
- W2800440897 doi "https://doi.org/10.22377/ajp.v12i01.1913" @default.
- W2800440897 hasPublicationYear "2018" @default.
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