FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800446919> ?p ?o ?g. }

• W2800446919 abstract "Our aim was to investigate the crosstalk between tumor and immune cells (M2 macrophages) and its effects on cyclo-oxygenase-2 (COX2) regulation in canine mammary tumors (CMT).Sh1b CMT cells and human BT474 mammary or HT29 colon cancer cells were co-cultured with canine peripheral blood mononuclear cells (PBMCs) or with macrophage-like differentiated THP1 monocytes (dTHP1). Intracellular COX2 expression by PBMCs, dTHP1 and cancer cells was evaluated by flow cytometry.Co-culturing of Sh1b and canine PBMCs induced COX2 overexpression in CMT cells. In turn, COX2 expression by PBMCs, mostly CD68+ macrophages, was attenuated by co-culture with Sh1b (p=0.0001). In accordance, co-culture with dTHP1 prompted intracellular production of COX2 in both Sh1b CMT cells and HT29 human colon cancer cells and reduced production of COX2 in BT474 human mammary cancer cells. The intracellular COX2 expression from dTHP1 decreased when treated with conditioned medium from cultured Sh1b and HT29 cancer cells.Bidirectional COX2 regulation between cancer and monocytes/macrophages might shape a tolerogenic tumor microenvironment in CMT." @default.
• W2800446919 created "2018-05-17" @default.
• W2800446919 creator A5005017881 @default.
• W2800446919 creator A5013270293 @default.
• W2800446919 creator A5022630477 @default.
• W2800446919 creator A5025795157 @default.
• W2800446919 creator A5031157956 @default.
• W2800446919 creator A5041475137 @default.
• W2800446919 creator A5086582855 @default.
• W2800446919 creator A5090061936 @default.
• W2800446919 creator A5091519172 @default.
• W2800446919 date "2018-05-02" @default.
• W2800446919 modified "2023-10-11" @default.
• W2800446919 title "Bidirectional Regulation of COX-2 Expression Between Cancer Cells and Macrophages" @default.
• W2800446919 cites W1805730758 @default.
• W2800446919 cites W1819769316 @default.
• W2800446919 cites W1897547428 @default.
• W2800446919 cites W1910476992 @default.
• W2800446919 cites W1912632292 @default.
• W2800446919 cites W1972348350 @default.
• W2800446919 cites W1972587327 @default.
• W2800446919 cites W1972835138 @default.
• W2800446919 cites W1991808539 @default.
• W2800446919 cites W1998779259 @default.
• W2800446919 cites W2002235017 @default.
• W2800446919 cites W2005885089 @default.
• W2800446919 cites W2050650884 @default.
• W2800446919 cites W2057796145 @default.
• W2800446919 cites W2062594956 @default.
• W2800446919 cites W2092590786 @default.
• W2800446919 cites W2094275934 @default.
• W2800446919 cites W2098791467 @default.
• W2800446919 cites W2117692326 @default.
• W2800446919 cites W2117894249 @default.
• W2800446919 cites W2118476293 @default.
• W2800446919 cites W2139239925 @default.
• W2800446919 cites W2139747116 @default.
• W2800446919 cites W2145453174 @default.
• W2800446919 cites W2145482502 @default.
• W2800446919 cites W2152064969 @default.
• W2800446919 cites W2162381561 @default.
• W2800446919 cites W2162929947 @default.
• W2800446919 cites W2166917655 @default.
• W2800446919 cites W2167810488 @default.
• W2800446919 cites W2168311342 @default.
• W2800446919 cites W2347059510 @default.
• W2800446919 cites W2737785069 @default.
• W2800446919 doi "https://doi.org/10.21873/anticanres.12525" @default.
• W2800446919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6342256" @default.
• W2800446919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29715103" @default.
• W2800446919 hasPublicationYear "2018" @default.
• W2800446919 type Work @default.
• W2800446919 sameAs 2800446919 @default.
• W2800446919 citedByCount "5" @default.
• W2800446919 countsByYear W28004469192019 @default.
• W2800446919 countsByYear W28004469192021 @default.
• W2800446919 countsByYear W28004469192022 @default.
• W2800446919 countsByYear W28004469192023 @default.
• W2800446919 crossrefType "journal-article" @default.
• W2800446919 hasAuthorship W2800446919A5005017881 @default.
• W2800446919 hasAuthorship W2800446919A5013270293 @default.
• W2800446919 hasAuthorship W2800446919A5022630477 @default.
• W2800446919 hasAuthorship W2800446919A5025795157 @default.
• W2800446919 hasAuthorship W2800446919A5031157956 @default.
• W2800446919 hasAuthorship W2800446919A5041475137 @default.
• W2800446919 hasAuthorship W2800446919A5086582855 @default.
• W2800446919 hasAuthorship W2800446919A5090061936 @default.
• W2800446919 hasAuthorship W2800446919A5091519172 @default.
• W2800446919 hasBestOaLocation W28004469191 @default.
• W2800446919 hasConcept C121608353 @default.
• W2800446919 hasConcept C126322002 @default.
• W2800446919 hasConcept C137061746 @default.
• W2800446919 hasConcept C153911025 @default.
• W2800446919 hasConcept C185592680 @default.
• W2800446919 hasConcept C202751555 @default.
• W2800446919 hasConcept C203014093 @default.
• W2800446919 hasConcept C204232928 @default.
• W2800446919 hasConcept C2776107976 @default.
• W2800446919 hasConcept C2776187077 @default.
• W2800446919 hasConcept C2776460901 @default.
• W2800446919 hasConcept C2779244956 @default.
• W2800446919 hasConcept C2781184567 @default.
• W2800446919 hasConcept C502942594 @default.
• W2800446919 hasConcept C530470458 @default.
• W2800446919 hasConcept C54355233 @default.
• W2800446919 hasConcept C553184892 @default.
• W2800446919 hasConcept C55493867 @default.
• W2800446919 hasConcept C71924100 @default.
• W2800446919 hasConcept C79879829 @default.
• W2800446919 hasConcept C81885089 @default.
• W2800446919 hasConcept C86803240 @default.
• W2800446919 hasConcept C8891405 @default.
• W2800446919 hasConcept C95444343 @default.
• W2800446919 hasConcept C96232424 @default.
• W2800446919 hasConceptScore W2800446919C121608353 @default.
• W2800446919 hasConceptScore W2800446919C126322002 @default.
• W2800446919 hasConceptScore W2800446919C137061746 @default.
• W2800446919 hasConceptScore W2800446919C153911025 @default.
• W2800446919 hasConceptScore W2800446919C185592680 @default.
• W2800446919 hasConceptScore W2800446919C202751555 @default.

• next