FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800452011> ?p ?o ?g. }

• W2800452011 endingPage "L347" @default.
• W2800452011 startingPage "L339" @default.
• W2800452011 abstract "Conventional resuscitation (CR) of hemorrhagic shock (HS), a significant cause of trauma mortality, is intravenous blood and fluids. CR restores central hemodynamics, but vital organ flow can drop, causing hypoperfusion, hypoxia, damage-associated molecular patterns (DAMPs), and remote organ dysfunction (i.e., lung). CR plus direct peritoneal resuscitation (DPR) prevents intestinal and hepatic hypoperfusion. We hypothesized that DPR prevents lung injury in HS/CR by altering DAMPs. Anesthetized male Sprague-Dawley rats were randomized to groups ( n = 8/group) in one of two sets: 1) sham (no HS, CR, or DPR), 2) HS/CR (HS = 40% mean arterial pressure (MAP) for 60 min, CR = shed blood + 2 volumes normal saline), or 3) HS/CR + DPR. The first set underwent whole lung blood flow by colorimetric microspheres. The second set underwent tissue collection for Luminex, ELISAs, and histopathology. Lipopolysaccharide (LPS) and DAMPs were measured in serum and/or lung, including cytokines, hyaluronic acid (HA), high-mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 protein (MYD88), and TIR-domain-containing adapter-inducing interferon-β (TRIF). Statistics were by ANOVA and Tukey-Kramer test with a priori P < 0.05. HS/CR increased serum LPS, HA, HMGB1, and some cytokines [interleukin (IL)-1α, IL-1β, IL-6, and interferon-γ]. Lung TLR4 and MYD88 were increased but not TRIF compared with Shams. HS/CR + DPR decreased LPS, HA, cytokines, HMGB1, TLR4, and MYD88 levels but did not alter TRIF compared with HS/CR. The data suggest that gut-derived DAMPs can be modulated by adjunctive DPR to prevent activation of lung TLR-4-mediated processes. Also, DPR improved lung blood flow and reduced lung tissue injury. Adjunctive DPR in HS/CR potentially improves morbidity and mortality by downregulating the systemic DAMP response." @default.
• W2800452011 created "2018-05-17" @default.
• W2800452011 creator A5015745014 @default.
• W2800452011 creator A5017532373 @default.
• W2800452011 creator A5033725162 @default.
• W2800452011 creator A5034942135 @default.
• W2800452011 creator A5052329713 @default.
• W2800452011 creator A5073013948 @default.
• W2800452011 creator A5086756031 @default.
• W2800452011 creator A5089874387 @default.
• W2800452011 date "2018-09-01" @default.
• W2800452011 modified "2023-09-26" @default.
• W2800452011 title "Damage-associated molecular patterns in resuscitated hemorrhagic shock are mitigated by peritoneal fluid administration" @default.
• W2800452011 cites W1169647102 @default.
• W2800452011 cites W1503343720 @default.
• W2800452011 cites W1691186793 @default.
• W2800452011 cites W1958361489 @default.
• W2800452011 cites W1966549549 @default.
• W2800452011 cites W1967859572 @default.
• W2800452011 cites W1987361003 @default.
• W2800452011 cites W2006131680 @default.
• W2800452011 cites W2009495759 @default.
• W2800452011 cites W2023108551 @default.
• W2800452011 cites W2040984882 @default.
• W2800452011 cites W2054439389 @default.
• W2800452011 cites W2055094488 @default.
• W2800452011 cites W2075035271 @default.
• W2800452011 cites W2077067540 @default.
• W2800452011 cites W2088746759 @default.
• W2800452011 cites W2089822346 @default.
• W2800452011 cites W2120366658 @default.
• W2800452011 cites W2140724463 @default.
• W2800452011 cites W2144039762 @default.
• W2800452011 cites W2148424389 @default.
• W2800452011 cites W2159854818 @default.
• W2800452011 cites W2164165676 @default.
• W2800452011 cites W2195721299 @default.
• W2800452011 cites W2197467506 @default.
• W2800452011 cites W2312604389 @default.
• W2800452011 cites W2321056371 @default.
• W2800452011 cites W2330566068 @default.
• W2800452011 cites W2519131163 @default.
• W2800452011 cites W2562850360 @default.
• W2800452011 cites W2588986585 @default.
• W2800452011 cites W4243401182 @default.
• W2800452011 cites W2304490052 @default.
• W2800452011 doi "https://doi.org/10.1152/ajplung.00183.2017" @default.
• W2800452011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29722563" @default.
• W2800452011 hasPublicationYear "2018" @default.
• W2800452011 type Work @default.
• W2800452011 sameAs 2800452011 @default.
• W2800452011 citedByCount "8" @default.
• W2800452011 countsByYear W28004520112021 @default.
• W2800452011 countsByYear W28004520112022 @default.
• W2800452011 countsByYear W28004520112023 @default.
• W2800452011 crossrefType "journal-article" @default.
• W2800452011 hasAuthorship W2800452011A5015745014 @default.
• W2800452011 hasAuthorship W2800452011A5017532373 @default.
• W2800452011 hasAuthorship W2800452011A5033725162 @default.
• W2800452011 hasAuthorship W2800452011A5034942135 @default.
• W2800452011 hasAuthorship W2800452011A5052329713 @default.
• W2800452011 hasAuthorship W2800452011A5073013948 @default.
• W2800452011 hasAuthorship W2800452011A5086756031 @default.
• W2800452011 hasAuthorship W2800452011A5089874387 @default.
• W2800452011 hasBestOaLocation W28004520111 @default.
• W2800452011 hasConcept C126322002 @default.
• W2800452011 hasConcept C136449434 @default.
• W2800452011 hasConcept C146957229 @default.
• W2800452011 hasConcept C16685009 @default.
• W2800452011 hasConcept C170493617 @default.
• W2800452011 hasConcept C203014093 @default.
• W2800452011 hasConcept C2776070231 @default.
• W2800452011 hasConcept C2776709828 @default.
• W2800452011 hasConcept C2777397205 @default.
• W2800452011 hasConcept C2777714996 @default.
• W2800452011 hasConcept C2778165595 @default.
• W2800452011 hasConcept C2778754761 @default.
• W2800452011 hasConcept C2780545709 @default.
• W2800452011 hasConcept C42219234 @default.
• W2800452011 hasConcept C43929388 @default.
• W2800452011 hasConcept C71924100 @default.
• W2800452011 hasConcept C8891405 @default.
• W2800452011 hasConcept C98274493 @default.
• W2800452011 hasConceptScore W2800452011C126322002 @default.
• W2800452011 hasConceptScore W2800452011C136449434 @default.
• W2800452011 hasConceptScore W2800452011C146957229 @default.
• W2800452011 hasConceptScore W2800452011C16685009 @default.
• W2800452011 hasConceptScore W2800452011C170493617 @default.
• W2800452011 hasConceptScore W2800452011C203014093 @default.
• W2800452011 hasConceptScore W2800452011C2776070231 @default.
• W2800452011 hasConceptScore W2800452011C2776709828 @default.
• W2800452011 hasConceptScore W2800452011C2777397205 @default.
• W2800452011 hasConceptScore W2800452011C2777714996 @default.
• W2800452011 hasConceptScore W2800452011C2778165595 @default.
• W2800452011 hasConceptScore W2800452011C2778754761 @default.
• W2800452011 hasConceptScore W2800452011C2780545709 @default.
• W2800452011 hasConceptScore W2800452011C42219234 @default.
• W2800452011 hasConceptScore W2800452011C43929388 @default.

• next