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• W2800459711 abstract "The rapid rise of antimicrobial resistance is one of the greatest challenges currently facing medical science. The most common cause of resistance to β-lactam antibiotics is the expression of β-lactamase enzymes, such as KPC-2. As such the development of novel inhibitors of KPC-2 and related enzymes is of the upmost importance. We report the design and synthesis of novel boronic acid transition state analogs containing a 1,4-substituted 1,2,3-triazole linker based on the known inhibitor 3-nitrophenyl boronic acid and demonstrate that they are promising scaffolds for the development inhibitors of KPC-2 with the ability to recover sensitivity to the antibiotic cefotaxime." @default.
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• W2800459711 date "2018-07-01" @default.
• W2800459711 modified "2023-10-07" @default.
• W2800459711 title "Boronic acid inhibitors of the class A β-lactamase KPC-2" @default.
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• W2800459711 doi "https://doi.org/10.1016/j.bmc.2018.04.055" @default.
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