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• W2800463877 abstract "Elevated testosterone (T) is routinely reported as a marker of hyperandrogenemia in rodent models for polycystic ovary syndrome (PCOS). In women with PCOS, elevated serum androstenedione (A4) is associated with more severe phenotypes, including a positive correlation with serum T, DHEAS, free androgen index (FAI), LH, and LH/FSH ratio. Furthermore, A4, along with calculated free T and FAI, was identified as one of the best predictors of PCOS in adult women of all ages (18 to > 50 y).The objective of this study was to investigate serum A4 levels in early adolescent and young adult prenatally androgenized (PNA) female rats, a model for PCOS.Pregnant rats were injected with 5 mg T daily during gestational days 16-19 (PNA rats, experimental group) or an equal volume of vehicle (control group). Female offspring of both groups had tail vein blood drawn for serum analysis at 8 and 16 weeks of age. ELISAs were used to quantify serum A4 and T levels.Serum A4 and T were elevated in 16-week-old PNA rats compared to controls. There was no significant difference in either hormone at 8 weeks of age.The PNA rats demonstrated elevated serum A4 and T in young adulthood, as has been observed in women with PCOS, further validating this as a model for PCOS and underscoring the importance of serum A4 elevation as a parameter inherent to PCOS and a rodent model for the disorder. Significant A4 elevation develops between early adolescence and early adulthood in this PNA rat model." @default.
• W2800463877 created "2018-05-17" @default.
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• W2800463877 date "2018-05-03" @default.
• W2800463877 modified "2023-10-14" @default.
• W2800463877 title "Elevated androstenedione in young adult but not early adolescent prenatally androgenized female rats" @default.
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• W2800463877 doi "https://doi.org/10.1371/journal.pone.0196862" @default.
• W2800463877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5933698" @default.
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• W2800463877 hasPublicationYear "2018" @default.
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