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- W2800471149 abstract "Abstract The purpose of this chapter is to explore the role of nanotechnology in Parkinson’s disease. Nanomaterials can be engineered to cross the blood–brain barrier, to target specific cells and molecules and to act as vehicles for drugs, enhancing their therapeutic efficacy and/or bioavailability. Nanotechnology has contributed significantly to the study of the pathogenesis of Parkinson’s disease. Nanoparticles can be used for early imaging of neuronal loss and nanodevices can help in the detection/quantification of amyloid peptides in cerebrospinal fluid. Nanomaterials have been studied in experimental models of Parkinson’s for the administration of antiparkinsonian agents, neurotrophic factors, antioxidants, neuroprotective and antiapoptotic factors. Nanotechnology-enabled naso-brain drug delivery, viral vectors, gene nanocarriers and exhaled breath analysis with nanoarray are other examples of nanotechnology applications. Nanotoxicity, however, is a realistic problem in mice and requires further investigation. In conclusion, nanotechnology has several applications potentially useful in the diagnosis and management of Parkinson’s disease patients." @default.
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- W2800471149 date "2018-01-01" @default.
- W2800471149 modified "2023-09-24" @default.
- W2800471149 title "Nanotechnology and Parkinson’s disease" @default.
- W2800471149 doi "https://doi.org/10.1016/b978-0-12-813667-6.00001-2" @default.
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