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- W2800471844 abstract "Summary Objective Emerging evidence supports a positive, bidirectional and clinical relevant interaction between parathyroid hormone ( PTH ) and the renin‐angiotensin‐aldosterone‐system ( RAAS ). A beneficial effect of the widely used RAAS inhibitors might include a PTH ‐lowering effect, as high PTH levels may be harmful to cardiovascular health. We aimed to investigate whether PTH levels are lowered by short‐term treatment with an angiotensin 2 receptor blocker (valsartan) independently of coadministration of vitamin D3. Secondary end‐points included effects on blood pressure, cardiac conduction and concentrations of renin and aldosterone. Design and Methods In a double‐blind placebo‐controlled trial, we included 81 otherwise healthy postmenopausal women with high PTH levels (>6.9 pmol/L) and vitamin D insufficiency (25( OH )D < 50 nmol/L). Participants received 2 weeks of treatment with valsartan 80 mg/d, vitamin D3 70 μg/d, valsartan plus vitamin D3 or double placebo. Results Valsartan treatment did not affect plasma PTH , although treatment reduced diastolic blood pressure ( P = .01) and the aldosterone/renin ratio ( P < .001). We found no associations between calciotropic hormones and RAAS markers. Vitamin D3 supplementation reduced PTH by 3.4% (25th, 75th −9.0 to 8.7) compared to a 7.1% increase (25th, 75th −2.4 to 30.9) in the placebo group ( P = .01), but did not affect blood pressure, cardiac conduction or concentrations of renin and aldosterone. Conclusions Independently of vitamin D3, short‐term valsartan treatment did not reduce PTH . Vitamin D3 reduced PTH but did not affect blood pressure, cardiac conduction or the RAAS . The study does not support a direct association between PTH and aldosterone or a blood pressure‐lowering effect of vitamin D3." @default.
- W2800471844 created "2018-05-17" @default.
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- W2800471844 date "2018-05-23" @default.
- W2800471844 modified "2023-10-14" @default.
- W2800471844 title "Effects of treatment with an angiotensin 2 receptor blocker and/or vitamin D3 on parathyroid hormone and aldosterone: A randomized, placebo-controlled trial" @default.
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- W2800471844 doi "https://doi.org/10.1111/cen.13734" @default.
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