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- W2800519552 abstract "We report a general and operationally simple method for the solid phase synthesis of α ‐ketoamide peptides using standard Fmoc solid phase peptide synthesis. The method delivers deprotected peptide α ‐ketoamides directly upon resin cleavage without any additional steps, and tolerates all side chain functional groups. A small collection of C‐terminal and internal α ‐ketoamide peptides – including two reported protease inhibitors ( HCV and SUB 1) – were prepared in good yields. In addition, we demonstrate that our method serves as versatile platform for the convenient preparation of cyclic α ‐ketoamide peptides, photocagged peptide α ‐ketoamides, and fluorescently labeled peptides." @default.
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- W2800519552 date "2018-05-01" @default.
- W2800519552 modified "2023-10-16" @default.
- W2800519552 title "Facile Synthesis of Internal and C‐Terminal Peptide <i>α</i>‐Ketoamides with Fmoc‐Solid Phase Peptide Synthesis" @default.
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- W2800519552 doi "https://doi.org/10.1002/hlca.201800039" @default.
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