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- W2800520902 abstract "Tofacitinib is an oral Janus kinase inhibitor, which is suggested to be effective for various skin diseases including psoriasis, atopic dermatitis and vitiligo. In vitiligo, IFNγ-STAT1-CXCL10 axis is crucial for its pathogenesis. Previous studies have suggested that blockade of this pathway would suppress the T cell recruitment to melanocyte leading to repigmentation, though, details of its mechanism are still to be clarified. In this study we investigated if tofacitinib may facilitate the melanocyte migration during repigmentation process by using mice model of rhododendrol-induced leukoderma (RIL). Hairless hk14-SCF transgenic mice with RIL were subjected for oral administration (25mg/kg) and topical application (1%) of tofacitinib for six weeks. Vehicle administration/application was set for negative control. During six-week observation period, there was no significant difference regarding the repigmentation rate between tofacitinib (both oral administration and topical application) and vehicle group. Current result demonstrates that tofacitinib does not facilitate repigmentation in RIL mice model, suggesting the efficacy of tofacitinib to vitiligo is likely due to immune-mediated process, not the facilitation of melanocyte migration." @default.
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- W2800520902 date "2018-05-01" @default.
- W2800520902 modified "2023-09-26" @default.
- W2800520902 title "1251 Janus kinase inhibitor tofacitinib does not facilitate the repigmentation in mice model of rhododendrol-induced leukoderma" @default.
- W2800520902 doi "https://doi.org/10.1016/j.jid.2018.03.1266" @default.
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