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- W2800530336 endingPage "1118" @default.
- W2800530336 startingPage "1104" @default.
- W2800530336 abstract "Age-related reduction in adult hippocampal neurogenesis is correlated with cognitive impairment. Diabetes is a chronic systemic disease that negatively affects adult neural stem cells and memory functions in the hippocampus. Despite growing concern regarding the potential role of diabetic drugs in neural abnormalities, their effects on progressive deterioration of neurogenesis and cognitive functions remain unknown. Here, we show that the combination of aging and diabetes in mice causes a marked decrease in hippocampal neurogenesis along with memory impairment and elevated neuroinflammation. Prolonged treatment with metformin, a biguanide antidiabetic medication, promotes cell proliferation and neuronal differentiation and inhibits aging- and diabetes-associated microglial activation, which is related to homeostatic neurogenesis, leading to enhanced hippocampal neurogenesis in middle-aged diabetic mice. Although chronic therapy with metformin fails to achieve recovery from hyperglycemia, a key feature of diabetes in middle-aged diabetic mice, it improves hippocampal-dependent spatial memory functions accompanied by increased phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), atypical protein kinase C ζ (aPKC ζ), and insulin receptor substrate 1 (IRS1) at selective serine residues in the hippocampus. Our findings suggest that signaling networks acting through long-term metformin-stimulated phosphorylation of AMPK, aPKC ζ/λ, and IRS1 serine sites contribute to neuroprotective effects on hippocampal neurogenesis and cognitive function independent of a hypoglycemic effect." @default.
- W2800530336 created "2018-05-17" @default.
- W2800530336 creator A5019160424 @default.
- W2800530336 creator A5020996592 @default.
- W2800530336 creator A5029382212 @default.
- W2800530336 creator A5034464133 @default.
- W2800530336 creator A5036815639 @default.
- W2800530336 creator A5040626070 @default.
- W2800530336 creator A5041907273 @default.
- W2800530336 creator A5063277933 @default.
- W2800530336 date "2018-05-18" @default.
- W2800530336 modified "2023-10-11" @default.
- W2800530336 title "Metformin treatment ameliorates diabetes‐associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1" @default.
- W2800530336 cites W1527925871 @default.
- W2800530336 cites W1553669285 @default.
- W2800530336 cites W1597817261 @default.
- W2800530336 cites W1600770312 @default.
- W2800530336 cites W1644011132 @default.
- W2800530336 cites W1662530116 @default.
- W2800530336 cites W1796267606 @default.
- W2800530336 cites W1913843018 @default.
- W2800530336 cites W1964345899 @default.
- W2800530336 cites W1967937854 @default.
- W2800530336 cites W1968242213 @default.
- W2800530336 cites W1969040512 @default.
- W2800530336 cites W1969905245 @default.
- W2800530336 cites W1970205234 @default.
- W2800530336 cites W1972862259 @default.
- W2800530336 cites W1972942987 @default.
- W2800530336 cites W1976619844 @default.
- W2800530336 cites W1977652492 @default.
- W2800530336 cites W1982479748 @default.
- W2800530336 cites W1982795519 @default.
- W2800530336 cites W1983644247 @default.
- W2800530336 cites W1985425785 @default.
- W2800530336 cites W1988869372 @default.
- W2800530336 cites W1989324173 @default.
- W2800530336 cites W1989550840 @default.
- W2800530336 cites W1991157753 @default.
- W2800530336 cites W1996371323 @default.
- W2800530336 cites W1999124715 @default.
- W2800530336 cites W1999971397 @default.
- W2800530336 cites W2000047954 @default.
- W2800530336 cites W2001599368 @default.
- W2800530336 cites W2003856043 @default.
- W2800530336 cites W2006505402 @default.
- W2800530336 cites W2011133554 @default.
- W2800530336 cites W2015197347 @default.
- W2800530336 cites W2020725735 @default.
- W2800530336 cites W2023455728 @default.
- W2800530336 cites W2033429522 @default.
- W2800530336 cites W2044150433 @default.
- W2800530336 cites W2045926149 @default.
- W2800530336 cites W2046983229 @default.
- W2800530336 cites W2050068554 @default.
- W2800530336 cites W2054552572 @default.
- W2800530336 cites W2055708395 @default.
- W2800530336 cites W2060817524 @default.
- W2800530336 cites W2065153078 @default.
- W2800530336 cites W2066924355 @default.
- W2800530336 cites W2078281362 @default.
- W2800530336 cites W2079156156 @default.
- W2800530336 cites W2080818732 @default.
- W2800530336 cites W2083849298 @default.
- W2800530336 cites W2086679674 @default.
- W2800530336 cites W2089119460 @default.
- W2800530336 cites W2089250607 @default.
- W2800530336 cites W2091698048 @default.
- W2800530336 cites W2096405787 @default.
- W2800530336 cites W2111215209 @default.
- W2800530336 cites W2111322904 @default.
- W2800530336 cites W2116721266 @default.
- W2800530336 cites W2118930057 @default.
- W2800530336 cites W2121009504 @default.
- W2800530336 cites W2122526759 @default.
- W2800530336 cites W2128367294 @default.
- W2800530336 cites W2129191282 @default.
- W2800530336 cites W2134406000 @default.
- W2800530336 cites W2136721455 @default.
- W2800530336 cites W2142272708 @default.
- W2800530336 cites W2146310895 @default.
- W2800530336 cites W2150472993 @default.
- W2800530336 cites W2171397809 @default.
- W2800530336 cites W2319472270 @default.
- W2800530336 cites W2320983896 @default.
- W2800530336 cites W2321697502 @default.
- W2800530336 cites W2411185224 @default.
- W2800530336 cites W2491034915 @default.
- W2800530336 cites W2499545266 @default.
- W2800530336 cites W2501462863 @default.
- W2800530336 cites W2584122878 @default.
- W2800530336 cites W2588720283 @default.
- W2800530336 cites W2604140581 @default.
- W2800530336 cites W2604933812 @default.
- W2800530336 cites W2615234683 @default.
- W2800530336 cites W2760843367 @default.
- W2800530336 cites W2771899481 @default.
- W2800530336 cites W4245367233 @default.