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• W280053547 abstract "Recent investigation of cell transplantation has provided new hope for the treatment of heart failure, a historically incurable disease. Although multiple cell types and delivery techniques have been employed, no clear consensus has been reached as to the superiority of any single method. Skeletal myoblasts have several unique properties that make them an attractive cell type for use in the clinical arena. Most importantly they are autologous, readily available, and easily harvested and expanded ex vivo. Furthermore, they can be modified genetically to optimize engraftment. Their successful use in animal studies has justified several clinical trials in the United States and Europe. Autologous engraftment of skeletal myoblasts in patients has been associated with modest improvements in cardiac function. The mechanisms by which these cells might exert their positive effect remain in question, but a direct contribution to contractile function seems unlikely. Enthusiasm for these cells has further been tempered by an apparent arrhythmogenic risk. This chapter explores the use of skeletal myoblasts for the treatment of heart failure. The preclinical and clinical data published to date are reviewed. The ultimate role of these cells in the clinical armamentarium of heart failure treatments will depend on the results of ongoing studies. Regardless of their future, the use of skeletal myoblasts has provided important insights in the burgeoning field of cell therapy for heart failure." @default.
• W280053547 created "2016-06-24" @default.
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• W280053547 date "2007-01-01" @default.
• W280053547 modified "2023-10-16" @default.
• W280053547 title "Use of Skeletal Myoblasts for the Treatment of Chronic Heart Failure" @default.
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• W280053547 doi "https://doi.org/10.1007/978-1-59745-272-4_18" @default.
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