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• W2800537445 abstract "Essential oils of some aromatic plants provide an effective nonmedicinal option to control liver fibrosis. Mentha piperita L. essential oil (MPEO) have been reported to possess protective effects against hepatotoxicity. However, its effect against liver fibrosis remains unknown. The present study investigated the antifibrogenic potential of MPEO and its underlying mechanisms. Forty male rats divided into 4 groups were used: group 1 served as normal control, group 2 (liver fibrosis) received CCl 4 (2.5 mL/kg, IP, twice weekly) for 8 weeks, group 3 concurrently received CCl 4 plus MPEO (50 mg/kg, IP, daily, from the 3rd week), and group 4 received MPEO only. MPOE significantly improved the liver injury markers, lipid peroxidation (LPO), antioxidant capacity, CYP2E1 gene expressionand liver histology. Furthermore, MPOE ameliorated liver fibrosis as evidenced by the reduced expression of desmin, α -smooth muscle actin ( α -SMA), transforming growth factor- β 1 (TGF- β 1), and SMAD3 proteins. In addition, MPOE counteracted the p53 upregulation induced by CCl 4 at both mRNA and protein levels. In conclusion, MPOE could effectively attenuate hepatic fibrosis mainly through improving the redox status, suppressing p53 and subsequently modulating TGF- β 1 and SMAD3 protein expression. These data promote the use of MPOE as a promising approach in antifibrotic therapy." @default.
• W2800537445 created "2018-05-17" @default.
• W2800537445 creator A5008864666 @default.
• W2800537445 creator A5036986690 @default.
• W2800537445 creator A5053913642 @default.
• W2800537445 date "2018-01-01" @default.
• W2800537445 modified "2023-09-23" @default.
• W2800537445 title "Antifibrogenic Influence of <i>Mentha piperita</i> L. Essential Oil against CCl₄-Induced Liver Fibrosis in Rats" @default.
• W2800537445 cites W1582826863 @default.
• W2800537445 cites W1772733387 @default.
• W2800537445 cites W1963343926 @default.
• W2800537445 cites W1964894862 @default.
• W2800537445 cites W1965026439 @default.
• W2800537445 cites W1973529620 @default.
• W2800537445 cites W1976886705 @default.
• W2800537445 cites W1978882265 @default.
• W2800537445 cites W1979106417 @default.
• W2800537445 cites W1981900811 @default.
• W2800537445 cites W1985314055 @default.
• W2800537445 cites W1990613923 @default.
• W2800537445 cites W1995666657 @default.
• W2800537445 cites W2003577377 @default.
• W2800537445 cites W2003599465 @default.
• W2800537445 cites W2004261523 @default.
• W2800537445 cites W2005942183 @default.
• W2800537445 cites W2006111363 @default.
• W2800537445 cites W2007500450 @default.
• W2800537445 cites W201653061 @default.
• W2800537445 cites W2017961355 @default.
• W2800537445 cites W2020010164 @default.
• W2800537445 cites W2021803123 @default.
• W2800537445 cites W2025722611 @default.
• W2800537445 cites W2026062091 @default.
• W2800537445 cites W2027756656 @default.
• W2800537445 cites W2027875827 @default.
• W2800537445 cites W2032674280 @default.
• W2800537445 cites W2033992157 @default.
• W2800537445 cites W2034955793 @default.
• W2800537445 cites W2036044995 @default.
• W2800537445 cites W2043683304 @default.
• W2800537445 cites W2046658455 @default.
• W2800537445 cites W2053482984 @default.
• W2800537445 cites W2055279192 @default.
• W2800537445 cites W2060717870 @default.
• W2800537445 cites W2063669247 @default.
• W2800537445 cites W2069176364 @default.
• W2800537445 cites W2069408625 @default.
• W2800537445 cites W2086815118 @default.
• W2800537445 cites W2087797145 @default.
• W2800537445 cites W2092887165 @default.
• W2800537445 cites W2094865102 @default.
• W2800537445 cites W2096795975 @default.
• W2800537445 cites W2097165440 @default.
• W2800537445 cites W2104193042 @default.
• W2800537445 cites W2104741594 @default.
• W2800537445 cites W2107277218 @default.
• W2800537445 cites W2123098050 @default.
• W2800537445 cites W2128635872 @default.
• W2800537445 cites W2128915011 @default.
• W2800537445 cites W2133959309 @default.
• W2800537445 cites W2135944288 @default.
• W2800537445 cites W2140563408 @default.
• W2800537445 cites W2144199622 @default.
• W2800537445 cites W2146390723 @default.
• W2800537445 cites W2149633452 @default.
• W2800537445 cites W2155663558 @default.
• W2800537445 cites W2159884299 @default.
• W2800537445 cites W2165457542 @default.
• W2800537445 cites W2166690382 @default.
• W2800537445 cites W2166874505 @default.
• W2800537445 cites W2192080449 @default.
• W2800537445 cites W2192625288 @default.
• W2800537445 cites W2256103742 @default.
• W2800537445 cites W2260402151 @default.
• W2800537445 cites W2263023695 @default.
• W2800537445 cites W2266929960 @default.
• W2800537445 cites W2407306947 @default.
• W2800537445 cites W2434941267 @default.
• W2800537445 cites W2468118389 @default.
• W2800537445 cites W2522193438 @default.
• W2800537445 cites W2546905330 @default.
• W2800537445 cites W2556048841 @default.
• W2800537445 cites W2558798644 @default.
• W2800537445 cites W2560137500 @default.
• W2800537445 cites W2562140498 @default.
• W2800537445 cites W2564546499 @default.
• W2800537445 cites W4250450758 @default.
• W2800537445 cites W4293247451 @default.
• W2800537445 cites W80469462 @default.
• W2800537445 cites W85375720 @default.
• W2800537445 cites W189472842 @default.
• W2800537445 cites W2084443898 @default.
• W2800537445 doi "https://doi.org/10.1155/2018/4039753" @default.
• W2800537445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5933010" @default.
• W2800537445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29849890" @default.
• W2800537445 hasPublicationYear "2018" @default.
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