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- W2800558446 abstract "Objective: Characterize ALS patients based on MIP/FVC at first visit Background: According to AAN 2009 practice parameters initiation of NIPPV is indicated with a FVC ≤ 50% OR when MIP ≤60 cmH20. We hope to replicate earlier studies to establish that MIP is a more sensitive indicator of hypoventilation than FVC. Further characterize patients based on MIP/FVC at first visit and analyze the effect of NIPPV use on class 1 subjects. Design/Methods: A retrospective database cohort study of 264 ALS patients 2014–2017. Demographics analysis with Kruskal-Wallis for nominal and Fischer’s exact for categorical variables. Patients categorized by FVC & MIP at first visit [C1: FVC≥50, MIP≥60, C2: FVC≥50, MIP≤60; C3: FVC≤50, MIP≤60]. Multi-visit analysis conducted for time to MIP≤60 & FVC≤50 for those not meeting NIPPV criteria at first visit. Longitudinal regression analysis of ALSFRS and Appel Score for C1 subjects using a time dependent model performed to evaluate the effect of NIPPV. Statistical significance set at P Results: 264 ALS (61.4yrs ± 11.9; 40% F; 21.2% bulbar, 18.7 mos. ± 15.2 disease duration; 81.2% riluzole). First visit, 8.7% met NIPPV criteria by FVC≤50 vs 58.33% by MIP≤60. For remaining (n=158), 74 reach FVC≤50% at 11.8 mos. ± 9.1 vs. 126 reaching MIP≤60 at 3.83 mos. ± 7.3, with FVC lagging by 7.94±7.8 mos. Greater proportion of older age, female gender, bulbar status, and faster pre-diagnosis progression noted in class II, III (MIP≤60) p Conclusions: MIP is sensitive, early indicator for NIPPV initiation. Older females with bulbar disease and faster rate of progression are likely to present at first visit meeting criteria for NIPPV by MIP, independent of FVC. NIPPV use significantly changed ALSFRS and Appel scores in class 1. Disclosure: Dr. Akkineni has nothing to disclose. Dr. Simpson has nothing to disclose. Dr. Holland has nothing to disclose. Dr. Peterson has nothing to disclose." @default.
- W2800558446 created "2018-05-17" @default.
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- W2800558446 date "2018-04-10" @default.
- W2800558446 modified "2023-09-23" @default.
- W2800558446 title "Characterization of ALS patients based on MIP & FVC at first visit (P4.434)" @default.
- W2800558446 hasPublicationYear "2018" @default.
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