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- W2800560382 abstract "Abstract The capacity of stem and progenitor cells to stimulate cardiac regeneration has been studied for almost 20 years, with very promising preclinical data and mixed clinical results. Several cell types have been studied, identified by their cell surface markers, differentiation capacity and their secreted growth factors. Bone marrow derived mesenchymal stem cells (MSCs) have been found to have potent regenerative capacity, through multiple mechanisms, including mesoderm lineage differentiation, immunomodulation, and paracrine stimulation. MSCs also secrete exosomes and microvesicles, which themselves contain potent angiogenic cytokines or mRNA molecules with effects on their local milieu. This concise review summarizes the mechanisms of MSC-based cardiac regeneration and highlighting results from molecular and preclinical studies. We also discuss clinical trial results to date, and ongoing studies. Furthermore, we discuss novel approaches for the enhancement of MSC based cardiac regeneration, such as genetic modification." @default.
- W2800560382 created "2018-05-17" @default.
- W2800560382 creator A5029417172 @default.
- W2800560382 creator A5031594150 @default.
- W2800560382 creator A5060475589 @default.
- W2800560382 date "2018-04-17" @default.
- W2800560382 modified "2023-10-16" @default.
- W2800560382 title "Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease" @default.
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- W2800560382 doi "https://doi.org/10.1002/sctm.17-0210" @default.
- W2800560382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6052612" @default.
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