FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800560985> ?p ?o ?g. }

• W2800560985 endingPage "393" @default.
• W2800560985 startingPage "381" @default.
• W2800560985 abstract "Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications. Understanding the treatment considerations specific to each class of T2DM medication is important in individualizing therapy and improving glycemic, renal, and cardiovascular outcomes. Traditional glucose-lowering treatments include insulin, metformin, sulfonylureas, meglitinides, and thiazolidinediones. Each of these agents exhibits altered pharmacokinetics in patients with renal impairment except for the thiazolidinediones, which are metabolized by the liver and do not accumulate appreciably in patients with renal impairment. Newer glucose-lowering treatments include GLP-1 receptor agonists, DPP-4 inhibitors, and SGLT2 inhibitors. Of these, only the DPP-4 inhibitor linagliptin can be used across all stages of renal impairment without dosing restrictions or concerns regarding dose escalation, and all SGLT2 inhibitors are contraindicated when eGFR <45 mL/min/1.73m2. Several of the newer treatments have also been investigated for effects on renal and cardiovascular outcomes, demonstrating potential benefits of the GLP-1 agonists liraglutide and semaglutide, as well as the SGLT2 inhibitors canagliflozin and empagliflozin, in reducing risk for some adverse renal and cardiovascular events. In addition, some DPP-4 inhibitors have been shown to reduce albuminuria, an indicator of glomerular dysfunction. Consideration of this information is useful in informing optimal management strategies for patients with T2DM and concomitant CKD. More clinical data from future and ongoing clinical trials, including data regarding potential renal and cardiovascular benefits, will be important in clarifying the safety and efficacy profiles of each of these agents in patients with CKD." @default.
• W2800560985 created "2018-05-17" @default.
• W2800560985 creator A5002625532 @default.
• W2800560985 creator A5058716877 @default.
• W2800560985 date "2018-04-18" @default.
• W2800560985 modified "2023-09-29" @default.
• W2800560985 title "Glycemic control of type 2 diabetes mellitus across stages of renal impairment: information for primary care providers" @default.
• W2800560985 cites W1526927233 @default.
• W2800560985 cites W1557233532 @default.
• W2800560985 cites W1582646839 @default.
• W2800560985 cites W1596678070 @default.
• W2800560985 cites W1726545321 @default.
• W2800560985 cites W1846464686 @default.
• W2800560985 cites W1887007488 @default.
• W2800560985 cites W1963571729 @default.
• W2800560985 cites W1996059294 @default.
• W2800560985 cites W1999421625 @default.
• W2800560985 cites W2001097346 @default.
• W2800560985 cites W2023749507 @default.
• W2800560985 cites W2026963340 @default.
• W2800560985 cites W2028317115 @default.
• W2800560985 cites W2028414002 @default.
• W2800560985 cites W2035321575 @default.
• W2800560985 cites W2042689611 @default.
• W2800560985 cites W2056857160 @default.
• W2800560985 cites W2060476230 @default.
• W2800560985 cites W2064130493 @default.
• W2800560985 cites W2072070798 @default.
• W2800560985 cites W2078089300 @default.
• W2800560985 cites W2111824270 @default.
• W2800560985 cites W2120251152 @default.
• W2800560985 cites W2120449552 @default.
• W2800560985 cites W2123472586 @default.
• W2800560985 cites W2123775770 @default.
• W2800560985 cites W2126508243 @default.
• W2800560985 cites W2126870113 @default.
• W2800560985 cites W2127125241 @default.
• W2800560985 cites W2127854619 @default.
• W2800560985 cites W2133980496 @default.
• W2800560985 cites W2138858019 @default.
• W2800560985 cites W2140536043 @default.
• W2800560985 cites W2142746038 @default.
• W2800560985 cites W2142830692 @default.
• W2800560985 cites W2144559080 @default.
• W2800560985 cites W2146264128 @default.
• W2800560985 cites W2146901298 @default.
• W2800560985 cites W2154719797 @default.
• W2800560985 cites W2155965977 @default.
• W2800560985 cites W2158666727 @default.
• W2800560985 cites W2160088494 @default.
• W2800560985 cites W2160461278 @default.
• W2800560985 cites W2161992213 @default.
• W2800560985 cites W2168023849 @default.
• W2800560985 cites W2178569306 @default.
• W2800560985 cites W2188846692 @default.
• W2800560985 cites W2213547035 @default.
• W2800560985 cites W2236659707 @default.
• W2800560985 cites W2282578582 @default.
• W2800560985 cites W2282647732 @default.
• W2800560985 cites W2282876332 @default.
• W2800560985 cites W2284028653 @default.
• W2800560985 cites W2325092926 @default.
• W2800560985 cites W2328041430 @default.
• W2800560985 cites W2335973015 @default.
• W2800560985 cites W2337454357 @default.
• W2800560985 cites W2407625702 @default.
• W2800560985 cites W2424539745 @default.
• W2800560985 cites W2425644022 @default.
• W2800560985 cites W2519510391 @default.
• W2800560985 cites W2530634871 @default.
• W2800560985 cites W2534221266 @default.
• W2800560985 cites W2562035449 @default.
• W2800560985 cites W2572398654 @default.
• W2800560985 cites W2575068279 @default.
• W2800560985 cites W2584815295 @default.
• W2800560985 cites W2595209157 @default.
• W2800560985 cites W2599428142 @default.
• W2800560985 cites W2600487630 @default.
• W2800560985 cites W2601983743 @default.
• W2800560985 cites W2624674854 @default.
• W2800560985 cites W2626446274 @default.
• W2800560985 cites W2639738157 @default.
• W2800560985 cites W2752707491 @default.
• W2800560985 cites W2754041380 @default.
• W2800560985 cites W2904387867 @default.
• W2800560985 cites W4211025575 @default.
• W2800560985 cites W4248927088 @default.
• W2800560985 doi "https://doi.org/10.1080/00325481.2018.1457397" @default.
• W2800560985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29667921" @default.
• W2800560985 hasPublicationYear "2018" @default.
• W2800560985 type Work @default.
• W2800560985 sameAs 2800560985 @default.
• W2800560985 citedByCount "22" @default.
• W2800560985 countsByYear W28005609852018 @default.
• W2800560985 countsByYear W28005609852019 @default.
• W2800560985 countsByYear W28005609852020 @default.
• W2800560985 countsByYear W28005609852021 @default.
• W2800560985 countsByYear W28005609852022 @default.

• next