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• W2800562560 endingPage "6399" @default.
• W2800562560 startingPage "6391" @default.
• W2800562560 abstract "This paper describes the synthesis of giant cyclic molecules having diameters of 10–20 nm. The molecules are prepared through the reactions of a fusion protein building block with small molecule linkers that are terminated in irreversible inhibitors of enzyme domains present in the fusion. This building block has N-terminal cutinase and C-terminal SnapTag domains that react irreversibly with p-nitrophenyl phosphonate (pNPP) and benzylguanine (BG) groups, respectively. We use a bis-BG and a BG-pNPP linker to join these fusion proteins into linear structures that can then react with a bis-pNPP linker that joins the ends into a cyclic product. The last step can occur intramolecularly, to give the macrocycle, or intermolecularly with another equivalent of linker, to give a linear product. Because these are coupled first- and second-order processes, an analysis of product yields from reactions performed at a range of linker concentrations gives rate constants for cyclization. We determined these to be 9.7 × 10–3 s–1, 2.3 × 10–3 s–1, and 8.1 × 10–4 s–1 for the dimer, tetramer, and hexamer, respectively. This work demonstrates an efficient route to cyclic macromolecules having nanoscale dimensions and provides new scaffolds that can be generated using the megamolecule approach." @default.
• W2800562560 created "2018-05-17" @default.
• W2800562560 creator A5020025866 @default.
• W2800562560 creator A5033408065 @default.
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• W2800562560 date "2018-05-03" @default.
• W2800562560 modified "2023-10-17" @default.
• W2800562560 title "Synthesis of Cyclic Megamolecules" @default.
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• W2800562560 doi "https://doi.org/10.1021/jacs.8b02665" @default.
• W2800562560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29723476" @default.
• W2800562560 hasPublicationYear "2018" @default.
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