FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800563576> ?p ?o ?g. }

• W2800563576 endingPage "1307" @default.
• W2800563576 startingPage "1298" @default.
• W2800563576 abstract "Well-tolerated, ribavirin-free, pangenotypic hepatitis C virus (HCV) treatments for transplant recipients remain a high priority. Once-daily glecaprevir/pibrentasvir demonstrates high rates of sustained virologic response at 12 weeks posttreatment (SVR12) across all major HCV genotypes (GTs). This trial evaluated the safety and efficacy of glecaprevir/pibrentasvir for patients with chronic HCV GT1-6 infection who had received a liver or kidney transplant. MAGELLAN-2 was a phase 3, open-label trial conducted in patients who were ≥3 months posttransplant. Patients without cirrhosis who were HCV treatment-naive (GT1-6) or treatment-experienced (GT1, 2, 4-6; with interferon-based therapy with or without sofosbuvir, or sofosbuvir plus ribavirin) received glecaprevir/pibrentasvir (300/120 mg) once daily for 12 weeks. The primary endpoint compared the percentage of patients receiving glecaprevir/pibrentasvir with SVR12 to a historic SVR12 rate based on the standard of care. Safety of glecaprevir/pibrentasvir was assessed. In total, 80 liver transplant and 20 kidney transplant patients participated in the trial. Most patients had no or minimal fibrosis (80% had fibrosis scores F0-F1) and were infected with HCV GT1 (57%) or GT3 (24%). The overall SVR12 was 98% (n/N = 98/100; 95% confidence interval, 95.3%-100%), which exceeded the prespecified historic standard-of-care SVR12 threshold of 94%. One patient experienced virologic failure. One patient discontinued because of an adverse event considered to be unrelated to treatment; this patient achieved SVR12. Adverse events were mostly mild in severity, and laboratory abnormalities were infrequent.Once-daily glecaprevir/pibrentasvir for 12 weeks is a well-tolerated and efficacious, ribavirin-free treatment for patients with chronic HCV GT1-6 infection who have received a liver or kidney transplant. (ClinicalTrials.gov NCT02692703.) (Hepatology 2018; 00:000-000)." @default.
• W2800563576 created "2018-05-17" @default.
• W2800563576 creator A5012984200 @default.
• W2800563576 creator A5014821725 @default.
• W2800563576 creator A5018915738 @default.
• W2800563576 creator A5025741164 @default.
• W2800563576 creator A5026511816 @default.
• W2800563576 creator A5028367378 @default.
• W2800563576 creator A5029165106 @default.
• W2800563576 creator A5035416018 @default.
• W2800563576 creator A5037697920 @default.
• W2800563576 creator A5039066540 @default.
• W2800563576 creator A5041306394 @default.
• W2800563576 creator A5045473449 @default.
• W2800563576 creator A5057586728 @default.
• W2800563576 creator A5066214063 @default.
• W2800563576 creator A5071037763 @default.
• W2800563576 creator A5073568589 @default.
• W2800563576 creator A5076393700 @default.
• W2800563576 creator A5077382409 @default.
• W2800563576 creator A5078808298 @default.
• W2800563576 creator A5082226670 @default.
• W2800563576 creator A5088842832 @default.
• W2800563576 creator A5091130570 @default.
• W2800563576 date "2018-07-25" @default.
• W2800563576 modified "2023-10-14" @default.
• W2800563576 title "Glecaprevir/Pibrentasvir Treatment in Liver or Kidney Transplant Patients With Hepatitis C Virus Infection" @default.
• W2800563576 cites W1881390415 @default.
• W2800563576 cites W2020577506 @default.
• W2800563576 cites W2029768048 @default.
• W2800563576 cites W2029944598 @default.
• W2800563576 cites W2059290576 @default.
• W2800563576 cites W2066264335 @default.
• W2800563576 cites W2077009218 @default.
• W2800563576 cites W2077531148 @default.
• W2800563576 cites W2113864802 @default.
• W2800563576 cites W2128390124 @default.
• W2800563576 cites W2158547060 @default.
• W2800563576 cites W2160289288 @default.
• W2800563576 cites W2163445383 @default.
• W2800563576 cites W2178839188 @default.
• W2800563576 cites W2180748603 @default.
• W2800563576 cites W2258122244 @default.
• W2800563576 cites W2277396963 @default.
• W2800563576 cites W2306227468 @default.
• W2800563576 cites W2315634424 @default.
• W2800563576 cites W2318197279 @default.
• W2800563576 cites W2418674843 @default.
• W2800563576 cites W2487282667 @default.
• W2800563576 cites W2517875316 @default.
• W2800563576 cites W2554701966 @default.
• W2800563576 cites W2559020624 @default.
• W2800563576 cites W2559030202 @default.
• W2800563576 cites W2588942442 @default.
• W2800563576 cites W2605698336 @default.
• W2800563576 cites W2667085915 @default.
• W2800563576 cites W2746084941 @default.
• W2800563576 cites W2751504895 @default.
• W2800563576 cites W2756644889 @default.
• W2800563576 cites W2761085897 @default.
• W2800563576 cites W2788216918 @default.
• W2800563576 cites W2992772421 @default.
• W2800563576 doi "https://doi.org/10.1002/hep.30046" @default.
• W2800563576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6220874" @default.
• W2800563576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29672891" @default.
• W2800563576 hasPublicationYear "2018" @default.
• W2800563576 type Work @default.
• W2800563576 sameAs 2800563576 @default.
• W2800563576 citedByCount "150" @default.
• W2800563576 countsByYear W28005635762018 @default.
• W2800563576 countsByYear W28005635762019 @default.
• W2800563576 countsByYear W28005635762020 @default.
• W2800563576 countsByYear W28005635762021 @default.
• W2800563576 countsByYear W28005635762022 @default.
• W2800563576 countsByYear W28005635762023 @default.
• W2800563576 crossrefType "journal-article" @default.
• W2800563576 hasAuthorship W2800563576A5012984200 @default.
• W2800563576 hasAuthorship W2800563576A5014821725 @default.
• W2800563576 hasAuthorship W2800563576A5018915738 @default.
• W2800563576 hasAuthorship W2800563576A5025741164 @default.
• W2800563576 hasAuthorship W2800563576A5026511816 @default.
• W2800563576 hasAuthorship W2800563576A5028367378 @default.
• W2800563576 hasAuthorship W2800563576A5029165106 @default.
• W2800563576 hasAuthorship W2800563576A5035416018 @default.
• W2800563576 hasAuthorship W2800563576A5037697920 @default.
• W2800563576 hasAuthorship W2800563576A5039066540 @default.
• W2800563576 hasAuthorship W2800563576A5041306394 @default.
• W2800563576 hasAuthorship W2800563576A5045473449 @default.
• W2800563576 hasAuthorship W2800563576A5057586728 @default.
• W2800563576 hasAuthorship W2800563576A5066214063 @default.
• W2800563576 hasAuthorship W2800563576A5071037763 @default.
• W2800563576 hasAuthorship W2800563576A5073568589 @default.
• W2800563576 hasAuthorship W2800563576A5076393700 @default.
• W2800563576 hasAuthorship W2800563576A5077382409 @default.
• W2800563576 hasAuthorship W2800563576A5078808298 @default.
• W2800563576 hasAuthorship W2800563576A5082226670 @default.
• W2800563576 hasAuthorship W2800563576A5088842832 @default.
• W2800563576 hasAuthorship W2800563576A5091130570 @default.

• next