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• W2800565210 abstract "Aims rs5219 is in Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene, located at 11p15.1. Researches on the association between rs5219 gene polymorphism with type 2 diabetes mellitus (T2DM) were performed extensively, but the results remain controversial. To investigate the relationship, a meta-analysis involving 21,464 individuals was conducted. Methods Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of this association. Publication bias was evaluated with Begg’s test. Our research includes three gene models: allelic genetic model (K-allele vs. E-allele), recessive genetic model (KK vs. EK + EE) and dominant genetic model (EE vs. EK + KK). Results In allelic genetic model, subgroup analysis demonstrated rs5219 K-allele was relevant to T2DM risk in Caucasian (OR: 1.16, 95% CI: 1.09–1.24, P = 0.000) and East Asian (OR: 1.19, 95% CI: 1.13–1.26, P = 0.000), recessive genetic model indicated rs5219 KK genotype was related to T2DM risk in Caucasian, East Asian, South Asian, and North African (OR: 1.27, 95% CI: 1.17–1.38, P = 0.000), dominant genetic model pointed out rs5219 EE genotype was an opposite association with T2DM risk in Caucasian (OR: 0.86, 95% CI: 0.78–0.94, P = 0.001). No obvious evidence of publication bias was found. Conclusions There was a believable evidence to verify that rs5219 variation was associated with T2DM." @default.
• W2800565210 created "2018-05-17" @default.
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• W2800565210 date "2018-08-01" @default.
• W2800565210 modified "2023-10-01" @default.
• W2800565210 title "Association of Kir6.2 gene rs5219 variation with type 2 diabetes: A meta-analysis of 21,464 individuals" @default.
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• W2800565210 doi "https://doi.org/10.1016/j.pcd.2018.03.004" @default.
• W2800565210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29685723" @default.
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