Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800566864> ?p ?o ?g. }
- W2800566864 abstract "HOXB9, as a HOX family transcription factor, playing a significant role in embryonic development and cancer progression. However, the function of HOXB9 and its precise mechanism in regulating endometrial cancer progression remains unknown. Here, we demonstrated that the expression of HOXB9 was increased in endometrial cancer, and associated with histological grade and lymph node metastasis. In addition, elevated HOXB9 predicts a poor prognosis in endometrial cancer patients. Interestingly, bioinformatics analysis of TCGA cancer database showed that HOXB9 expression is positively correlated with E2F3 expression. Moreover, HOXB9 promoted E2F3 expression by directly targeting to its promoter. Furthermore, we found that knocking down E2F3 abolished the ability of HOXB9 in enhancing cell migration. Taken together, for the first, we demonstrated the function and mechanism of HOXB9 in regulating endometrial cancer progression, and indicated HOXB9 may be a novel prognostic marker of endometrial cancer." @default.
- W2800566864 created "2018-05-17" @default.
- W2800566864 creator A5032501502 @default.
- W2800566864 creator A5041748603 @default.
- W2800566864 creator A5049474681 @default.
- W2800566864 creator A5061521296 @default.
- W2800566864 creator A5083095344 @default.
- W2800566864 date "2018-05-03" @default.
- W2800566864 modified "2023-10-12" @default.
- W2800566864 title "HOXB9 promotes endometrial cancer progression by targeting E2F3" @default.
- W2800566864 cites W1576770999 @default.
- W2800566864 cites W1922567675 @default.
- W2800566864 cites W1966868488 @default.
- W2800566864 cites W1969025265 @default.
- W2800566864 cites W1975611813 @default.
- W2800566864 cites W1982580103 @default.
- W2800566864 cites W1985348819 @default.
- W2800566864 cites W1985980474 @default.
- W2800566864 cites W1988141621 @default.
- W2800566864 cites W1997231384 @default.
- W2800566864 cites W2004151275 @default.
- W2800566864 cites W2005498969 @default.
- W2800566864 cites W2006788765 @default.
- W2800566864 cites W2013761002 @default.
- W2800566864 cites W2031207634 @default.
- W2800566864 cites W2043984491 @default.
- W2800566864 cites W2047061331 @default.
- W2800566864 cites W2048164783 @default.
- W2800566864 cites W2050817299 @default.
- W2800566864 cites W2051646582 @default.
- W2800566864 cites W2072727418 @default.
- W2800566864 cites W2082611751 @default.
- W2800566864 cites W2090384629 @default.
- W2800566864 cites W2101919861 @default.
- W2800566864 cites W2118498323 @default.
- W2800566864 cites W2119958264 @default.
- W2800566864 cites W2121727754 @default.
- W2800566864 cites W2125096346 @default.
- W2800566864 cites W2130987233 @default.
- W2800566864 cites W2139455010 @default.
- W2800566864 cites W2145191832 @default.
- W2800566864 cites W2149139293 @default.
- W2800566864 cites W2200180688 @default.
- W2800566864 cites W2507882863 @default.
- W2800566864 cites W2558255826 @default.
- W2800566864 cites W2570618306 @default.
- W2800566864 cites W2591860113 @default.
- W2800566864 cites W2606709102 @default.
- W2800566864 cites W2607129810 @default.
- W2800566864 cites W2767377392 @default.
- W2800566864 cites W2768310040 @default.
- W2800566864 cites W2770355315 @default.
- W2800566864 cites W2771812963 @default.
- W2800566864 cites W4241756178 @default.
- W2800566864 cites W4254829742 @default.
- W2800566864 cites W3011267628 @default.
- W2800566864 doi "https://doi.org/10.1038/s41419-018-0556-3" @default.
- W2800566864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5938704" @default.
- W2800566864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29724991" @default.
- W2800566864 hasPublicationYear "2018" @default.
- W2800566864 type Work @default.
- W2800566864 sameAs 2800566864 @default.
- W2800566864 citedByCount "46" @default.
- W2800566864 countsByYear W28005668642018 @default.
- W2800566864 countsByYear W28005668642019 @default.
- W2800566864 countsByYear W28005668642020 @default.
- W2800566864 countsByYear W28005668642021 @default.
- W2800566864 countsByYear W28005668642022 @default.
- W2800566864 countsByYear W28005668642023 @default.
- W2800566864 crossrefType "journal-article" @default.
- W2800566864 hasAuthorship W2800566864A5032501502 @default.
- W2800566864 hasAuthorship W2800566864A5041748603 @default.
- W2800566864 hasAuthorship W2800566864A5049474681 @default.
- W2800566864 hasAuthorship W2800566864A5061521296 @default.
- W2800566864 hasAuthorship W2800566864A5083095344 @default.
- W2800566864 hasBestOaLocation W28005668641 @default.
- W2800566864 hasConcept C104317684 @default.
- W2800566864 hasConcept C121608353 @default.
- W2800566864 hasConcept C126322002 @default.
- W2800566864 hasConcept C2777088508 @default.
- W2800566864 hasConcept C2779013556 @default.
- W2800566864 hasConcept C2779256057 @default.
- W2800566864 hasConcept C2992571226 @default.
- W2800566864 hasConcept C502942594 @default.
- W2800566864 hasConcept C54355233 @default.
- W2800566864 hasConcept C71924100 @default.
- W2800566864 hasConcept C86339819 @default.
- W2800566864 hasConcept C86803240 @default.
- W2800566864 hasConceptScore W2800566864C104317684 @default.
- W2800566864 hasConceptScore W2800566864C121608353 @default.
- W2800566864 hasConceptScore W2800566864C126322002 @default.
- W2800566864 hasConceptScore W2800566864C2777088508 @default.
- W2800566864 hasConceptScore W2800566864C2779013556 @default.
- W2800566864 hasConceptScore W2800566864C2779256057 @default.
- W2800566864 hasConceptScore W2800566864C2992571226 @default.
- W2800566864 hasConceptScore W2800566864C502942594 @default.
- W2800566864 hasConceptScore W2800566864C54355233 @default.
- W2800566864 hasConceptScore W2800566864C71924100 @default.
- W2800566864 hasConceptScore W2800566864C86339819 @default.
- W2800566864 hasConceptScore W2800566864C86803240 @default.