FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800570317> ?p ?o ?g. }

• W2800570317 endingPage "1871" @default.
• W2800570317 startingPage "1861" @default.
• W2800570317 abstract "Ultraviolet radiation (UVR) predominantly induces UV-signature mutations, C → T and CC → TT base substitutions at dipyrimidine sites, in the cellular and skin genome. I observed in our in vivo mutation studies of mouse skin that these UVR-specific mutations show a wavelength-dependent variation in their sequence-context preference. The C → T mutation occurs most frequently in the 5'-TCG-3' sequence regardless of the UVR wavelength, but is recovered more preferentially there as the wavelength increases, resulting in prominent occurrences exclusively in the TCG sequence in the UVA wavelength range, which I will designate as a UVA signature in this review. The preference of the UVB-induced C → T mutation for the sequence contexts shows a mixed pattern of UVC- and UVA-induced mutations, and a similar pattern is also observed for natural sunlight, in which UVB is the most genotoxic component. In addition, the CC → TT mutation hardly occurs at UVA1 wavelengths, although it is detected rarely but constantly in the UVC and UVB ranges. This wavelength-dependent variation in the sequence-context preference of the UVR-specific mutations could be explained by two different photochemical mechanisms of cyclobutane pyrimidine dimer (CPD) formation. The UV-signature mutations observed in the UVC and UVB ranges are known to be caused mainly by CPDs produced through the conventional singlet/triplet excitation of pyrimidine bases after the direct absorption of the UVC/UVB photon energy in those bases. On the other hand, a novel photochemical mechanism through the direct absorption of the UVR energy to double-stranded DNA, which is called collective excitation, has been proposed for the UVA-induced CPD formation. The UVA photons directly absorbed by DNA produce CPDs with a sequence context preference different from that observed for CPDs caused by the UVC/UVB-mediated singlet/triplet excitation, causing CPD formation preferentially at thymine-containing dipyrimidine sites and probably also preferably at methyl CpG-associated dipyrimidine sites, which include the TCG sequence. In this review, I present a mechanistic consideration on the wavelength-dependent variation of the sequence context preference of the UVR-specific mutations and rationalize the proposition of the UVA-signature mutation, in addition to the UV-signature mutation." @default.
• W2800570317 created "2018-05-17" @default.
• W2800570317 creator A5029539050 @default.
• W2800570317 date "2018-12-01" @default.
• W2800570317 modified "2023-09-26" @default.
• W2800570317 title "Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation" @default.
• W2800570317 cites W1545840572 @default.
• W2800570317 cites W1552078262 @default.
• W2800570317 cites W1581236180 @default.
• W2800570317 cites W1709525116 @default.
• W2800570317 cites W1767203358 @default.
• W2800570317 cites W1770654987 @default.
• W2800570317 cites W1873610357 @default.
• W2800570317 cites W1956871134 @default.
• W2800570317 cites W1963681298 @default.
• W2800570317 cites W1965733641 @default.
• W2800570317 cites W1966360175 @default.
• W2800570317 cites W1966496238 @default.
• W2800570317 cites W1966823058 @default.
• W2800570317 cites W1967629365 @default.
• W2800570317 cites W1968679294 @default.
• W2800570317 cites W1968886488 @default.
• W2800570317 cites W1969178576 @default.
• W2800570317 cites W1969853783 @default.
• W2800570317 cites W1971397036 @default.
• W2800570317 cites W1973729554 @default.
• W2800570317 cites W1974383197 @default.
• W2800570317 cites W1978593193 @default.
• W2800570317 cites W1979030206 @default.
• W2800570317 cites W1983180437 @default.
• W2800570317 cites W1984128578 @default.
• W2800570317 cites W1984290310 @default.
• W2800570317 cites W1985713945 @default.
• W2800570317 cites W1986076152 @default.
• W2800570317 cites W1987409548 @default.
• W2800570317 cites W1987799803 @default.
• W2800570317 cites W1990345329 @default.
• W2800570317 cites W1992294575 @default.
• W2800570317 cites W1993663419 @default.
• W2800570317 cites W1994639228 @default.
• W2800570317 cites W1995010848 @default.
• W2800570317 cites W1995367024 @default.
• W2800570317 cites W1995723021 @default.
• W2800570317 cites W1996127194 @default.
• W2800570317 cites W1997972400 @default.
• W2800570317 cites W1998439415 @default.
• W2800570317 cites W2002247801 @default.
• W2800570317 cites W2004512099 @default.
• W2800570317 cites W2005289526 @default.
• W2800570317 cites W2006803834 @default.
• W2800570317 cites W2009430092 @default.
• W2800570317 cites W2011883398 @default.
• W2800570317 cites W2013402232 @default.
• W2800570317 cites W2019108282 @default.
• W2800570317 cites W2020396623 @default.
• W2800570317 cites W2020657751 @default.
• W2800570317 cites W2022049642 @default.
• W2800570317 cites W2023382436 @default.
• W2800570317 cites W2028528554 @default.
• W2800570317 cites W2029755516 @default.
• W2800570317 cites W2032445218 @default.
• W2800570317 cites W2035167857 @default.
• W2800570317 cites W2037402820 @default.
• W2800570317 cites W2039495549 @default.
• W2800570317 cites W2045775784 @default.
• W2800570317 cites W2048607797 @default.
• W2800570317 cites W2051435128 @default.
• W2800570317 cites W2063046839 @default.
• W2800570317 cites W2063240589 @default.
• W2800570317 cites W2063416510 @default.
• W2800570317 cites W2063421549 @default.
• W2800570317 cites W2070184285 @default.
• W2800570317 cites W2073261425 @default.
• W2800570317 cites W2074010178 @default.
• W2800570317 cites W2077373507 @default.
• W2800570317 cites W2077459010 @default.
• W2800570317 cites W2078531129 @default.
• W2800570317 cites W2081683065 @default.
• W2800570317 cites W2083651366 @default.
• W2800570317 cites W2084251463 @default.
• W2800570317 cites W2085676932 @default.
• W2800570317 cites W2085719635 @default.
• W2800570317 cites W2086376495 @default.
• W2800570317 cites W2087406053 @default.
• W2800570317 cites W2090287369 @default.
• W2800570317 cites W2091113845 @default.
• W2800570317 cites W2092217630 @default.
• W2800570317 cites W2092508311 @default.
• W2800570317 cites W2092873988 @default.
• W2800570317 cites W2093971029 @default.
• W2800570317 cites W2094909600 @default.
• W2800570317 cites W2103890484 @default.
• W2800570317 cites W2111054184 @default.
• W2800570317 cites W2113716833 @default.
• W2800570317 cites W2117808727 @default.
• W2800570317 cites W2127144937 @default.
• W2800570317 cites W2127731553 @default.
• W2800570317 cites W2127967819 @default.

• next