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• W2800597578 abstract "Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years. Importantly, the CV system is particularly sensitive to the metabolic and immune derangements present in obese pre-diabetic and diabetic individuals; consequently, CV dysfunction is often the initial CV derangement to occur and promotes the progression to end organ/tissue damage in T2DM. Specifically, diabetic CVD can manifest as microvascular complications, such as nephropathy, retinopathy, and neuropathy, as well as, macrovascular impairments, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease. Despite some progress in prevention and treatment of CVD, mainly via blood pressure and dyslipidemia control strategies, the impact of metabolic disease on CV outcomes is still a major challenge and persists in proportion to the epidemics of obesity and diabetes. There is abundant pre-clinical and clinical evidence implicating the DPP-4-incretin axis in CVD. In this regard, linagliptin is a unique DPP-4 inhibitor with both CV and renal safety profiles. Moreover, it exerts beneficial CV effects beyond glycemic control and beyond class effects. Linagliptin is protective for both macrovascular and microvascular complications of diabetes in preclinical models, as well as clinical models. Given the role of endothelial-immune cell interactions as one of the key events in the initiation and progression of CVD, linagliptin modulates these cell-cell interactions by affecting two important pathways involving stimulation of NO signaling and potent inhibition of a key immunoregulatory molecule." @default.
• W2800597578 created "2018-05-17" @default.
• W2800597578 creator A5015218081 @default.
• W2800597578 creator A5018617193 @default.
• W2800597578 creator A5036556067 @default.
• W2800597578 date "2018-04-18" @default.
• W2800597578 modified "2023-10-13" @default.
• W2800597578 title "The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin" @default.
• W2800597578 cites W1119734502 @default.
• W2800597578 cites W1122748781 @default.
• W2800597578 cites W1502728584 @default.
• W2800597578 cites W1526784932 @default.
• W2800597578 cites W1595377541 @default.
• W2800597578 cites W1869057116 @default.
• W2800597578 cites W1887007488 @default.
• W2800597578 cites W1915743732 @default.
• W2800597578 cites W1951373717 @default.
• W2800597578 cites W1963858032 @default.
• W2800597578 cites W1965840130 @default.
• W2800597578 cites W1969068062 @default.
• W2800597578 cites W1969622949 @default.
• W2800597578 cites W1970020213 @default.
• W2800597578 cites W1973460974 @default.
• W2800597578 cites W1975588287 @default.
• W2800597578 cites W1982522510 @default.
• W2800597578 cites W1984070396 @default.
• W2800597578 cites W1985402074 @default.
• W2800597578 cites W1987885913 @default.
• W2800597578 cites W1987900761 @default.
• W2800597578 cites W1988068931 @default.
• W2800597578 cites W1995866677 @default.
• W2800597578 cites W1996724385 @default.
• W2800597578 cites W1998882505 @default.
• W2800597578 cites W1999440828 @default.
• W2800597578 cites W2005146299 @default.
• W2800597578 cites W2006473328 @default.
• W2800597578 cites W2006804028 @default.
• W2800597578 cites W2007374852 @default.
• W2800597578 cites W2009739504 @default.
• W2800597578 cites W2011849709 @default.
• W2800597578 cites W2012209979 @default.
• W2800597578 cites W2013710547 @default.
• W2800597578 cites W2016632734 @default.
• W2800597578 cites W2017221955 @default.
• W2800597578 cites W2017809993 @default.
• W2800597578 cites W2018799227 @default.
• W2800597578 cites W2019480343 @default.
• W2800597578 cites W2022119612 @default.
• W2800597578 cites W2022765352 @default.
• W2800597578 cites W2041375230 @default.
• W2800597578 cites W2044076817 @default.
• W2800597578 cites W2045846363 @default.
• W2800597578 cites W2049796688 @default.
• W2800597578 cites W2050875709 @default.
• W2800597578 cites W2051628797 @default.
• W2800597578 cites W2051951378 @default.
• W2800597578 cites W2055499860 @default.
• W2800597578 cites W2059079195 @default.
• W2800597578 cites W2059712263 @default.
• W2800597578 cites W2059903872 @default.
• W2800597578 cites W2060124483 @default.
• W2800597578 cites W2061250188 @default.
• W2800597578 cites W2062686485 @default.
• W2800597578 cites W2064130493 @default.
• W2800597578 cites W2064277057 @default.
• W2800597578 cites W2064941558 @default.
• W2800597578 cites W2065372294 @default.
• W2800597578 cites W2065836621 @default.
• W2800597578 cites W2072411085 @default.
• W2800597578 cites W2073841569 @default.
• W2800597578 cites W2079523154 @default.
• W2800597578 cites W2079784333 @default.
• W2800597578 cites W2080567113 @default.
• W2800597578 cites W2088248157 @default.
• W2800597578 cites W2094758439 @default.
• W2800597578 cites W2096796741 @default.
• W2800597578 cites W2096971003 @default.
• W2800597578 cites W2098047743 @default.
• W2800597578 cites W2099184406 @default.
• W2800597578 cites W2099475256 @default.
• W2800597578 cites W2102849202 @default.
• W2800597578 cites W2102945856 @default.
• W2800597578 cites W2104391911 @default.
• W2800597578 cites W2106888324 @default.
• W2800597578 cites W2109019361 @default.
• W2800597578 cites W2109288527 @default.
• W2800597578 cites W2110725041 @default.
• W2800597578 cites W2111230914 @default.
• W2800597578 cites W2111538581 @default.
• W2800597578 cites W2113985146 @default.
• W2800597578 cites W2114623841 @default.
• W2800597578 cites W2114792859 @default.
• W2800597578 cites W2115653936 @default.
• W2800597578 cites W2115932722 @default.
• W2800597578 cites W2116470621 @default.
• W2800597578 cites W2116878783 @default.
• W2800597578 cites W2116898765 @default.
• W2800597578 cites W2118090274 @default.
• W2800597578 cites W2118812428 @default.
• W2800597578 cites W2121115903 @default.

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