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- W2800646912 abstract "Statin exposure and nonmelanoma skin cancer (NMSC) association is unclear. The aim of this study is to determine if there is an association between statin exposure and NMSC [basal cell cancer (BCC) and squamous cell cancer (SCC)], in a large patient population. The Northwestern Medicine Enterprise Data Warehouse medical record data repository (> 5 million patients) was searched for patients aged 18-89 years with at least 5 years of in-clinic follow-up. The statin-exposed population consisted of all patients taking a chronic statin medication (atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or simvastatin) for at least 12 months, while the control population consisted of non-statin-exposed patients. Data on age, gender, race, and NMSC diagnosis were collected. Adjusted odds ratios (aORs) were determined by multivariate logistic regression. Of 440,289 patients meeting inclusion criteria, 56,117 had statin exposure, of whom 3,590 (6.4%) were diagnosed with NMSC, yielding a significant association between NMSC and statin exposure (aOR: 2.39; 95%CI 2.30-2.49; p < 0.0001). Data for the 40 to 75-year-old group chosen to follow recent statin recommendations from US Preventative Services Task Force also showed a significant association between statin exposure and subsequent NMSC diagnosis (aOR: 1.63; 95%CI 1.56-1.70; p < 0.0001). In addition, statin exposure and subsequent diagnoses of BCC or SCC were examined in separate populations. This yielded further significant associations between statin exposure and subsequent BCC diagnosis (aOR: 1.46; 95%CI 1.38-1.53; p < 0.0001), as well as subsequent SCC diagnosis (aOR: 2.12; 95%CI 1.97-2.29; p < 0.0001). These findings highlight an association between chronic statin exposure and subsequent incident NMSC in the study population." @default.
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- W2800646912 date "2018-05-01" @default.
- W2800646912 modified "2023-09-25" @default.
- W2800646912 title "242 Risk of nonmelanoma skin cancer after exposure to statin drugs: A report from the RADAR (Research on Adverse Drug events and Reports) project" @default.
- W2800646912 doi "https://doi.org/10.1016/j.jid.2018.03.248" @default.
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