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• W2800648052 abstract "The purpose of this study was to evaluate the effects of BMP-2 on bone-grafting procedures for the treatment of fibrous dysplasia based on in vitro and in vivo experiments.Proliferation of stem cells was determined by colony-forming assay, CCK-8 assay and BrdU staining. OCT4 and NANOG expression was analysed by flow cytometry and immunocytochemistry. Osteogenic differentiation was assessed by measuring ALP activity, Alizarin red S staining and in vivo transplantation. Gene expression of the osteogenic markers, osteocalcin and type 1 collagen, was determined by RT-PCR.FD-BMSCs showed few calcium deposits and low ALP activity. Bone formation by transplanted FD-BMSCs was also suppressed relative to that of normal BMSCs. However, BMP-2 treatment enhanced osteogenic differentiation of FD-BMSCs mixed with normal BMSCs in vitro and in vivo. Overall, BMP-2 treatment promoted osteogenic differentiation of FD-BMSCs mixed with normal BMSCs.In patients with FD, stem cells in affected bone are influenced by the mutation, resulting in weak bone formation with the proliferation of immature osteogenic cells. Current treatment of FD involves surgical removal of excess bulk lesions, which can cause facial disfigurement. Our results suggest that BMP-2 application is a good adjunctive modality to the surgical treatment of patients with FD." @default.
• W2800648052 created "2018-05-17" @default.
• W2800648052 creator A5020130980 @default.
• W2800648052 creator A5061328840 @default.
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• W2800648052 date "2018-07-04" @default.
• W2800648052 modified "2023-09-24" @default.
• W2800648052 title "Effects of BMP-2 on the osteogenic differentiation of bone marrow stem cells in fibrous dysplasia" @default.
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• W2800648052 doi "https://doi.org/10.1111/odi.12869" @default.
• W2800648052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29667269" @default.
• W2800648052 hasPublicationYear "2018" @default.
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