Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800650801> ?p ?o ?g. }
- W2800650801 abstract "Over the last decade, improved understanding of the mechanisms and structures of proteins integral to apoptosis have enabled therapeutic targeting of BCL2 to become more specific, less toxic and ultimately more clinically effective. The first BCL2-selective inhibitor, venetoclax, is now approved for use in patients with relapsed and refractory chronic lymphocytic leukemia (CLL) in multiple countries. Early phase clinical trials demonstrated an 80% overall response rates in patients with relapsed/refractory CLL, independent of traditional risk factors, without undue toxicity. Venetoclax is also highly active in other lymphoid malignancies that express high levels of its target, BCL2, such as mantle cell lymphoma. However, there is a cumulative incidence of disease progression while on therapy. Ongoing follow-up of the early phase trials is only now enabling elucidation of the incidence and risk factors for disease progression and treatment failure. Preventing development of resistance to BCL2 inhibition requires further research aimed at delineating the genetic and epigenetic drivers of disease progression. This will facilitate targeting of resistance mechanisms through the use of rational drug combinations, help to prospectively identify patients most likely to benefit and abet early identification of emerging resistance. These therapies are improving outcomes for patients with previously poor prognosis disease." @default.
- W2800650801 created "2018-05-17" @default.
- W2800650801 creator A5081326206 @default.
- W2800650801 creator A5090348753 @default.
- W2800650801 creator A5090470607 @default.
- W2800650801 date "2018-01-01" @default.
- W2800650801 modified "2023-09-27" @default.
- W2800650801 title "BCL2 Inhibitors: Insights into Resistance" @default.
- W2800650801 cites W1429374962 @default.
- W2800650801 cites W1489284756 @default.
- W2800650801 cites W1591166893 @default.
- W2800650801 cites W161836838 @default.
- W2800650801 cites W1851949377 @default.
- W2800650801 cites W1966407423 @default.
- W2800650801 cites W1972091733 @default.
- W2800650801 cites W1973001092 @default.
- W2800650801 cites W1978442810 @default.
- W2800650801 cites W1983477246 @default.
- W2800650801 cites W1984547206 @default.
- W2800650801 cites W2001850157 @default.
- W2800650801 cites W2008898220 @default.
- W2800650801 cites W2010571756 @default.
- W2800650801 cites W2013624622 @default.
- W2800650801 cites W2017339352 @default.
- W2800650801 cites W2021964934 @default.
- W2800650801 cites W2024341906 @default.
- W2800650801 cites W2027395744 @default.
- W2800650801 cites W2032361307 @default.
- W2800650801 cites W2034269086 @default.
- W2800650801 cites W2036274324 @default.
- W2800650801 cites W2038683465 @default.
- W2800650801 cites W2039640090 @default.
- W2800650801 cites W2050702798 @default.
- W2800650801 cites W2057693225 @default.
- W2800650801 cites W2058015212 @default.
- W2800650801 cites W2059162919 @default.
- W2800650801 cites W2059500638 @default.
- W2800650801 cites W2062358377 @default.
- W2800650801 cites W2064759291 @default.
- W2800650801 cites W2066640259 @default.
- W2800650801 cites W2071549499 @default.
- W2800650801 cites W2074077303 @default.
- W2800650801 cites W2081379689 @default.
- W2800650801 cites W2083175653 @default.
- W2800650801 cites W2085419794 @default.
- W2800650801 cites W2095447519 @default.
- W2800650801 cites W2096735689 @default.
- W2800650801 cites W2102461774 @default.
- W2800650801 cites W2110624435 @default.
- W2800650801 cites W2113278680 @default.
- W2800650801 cites W2113810545 @default.
- W2800650801 cites W2117692326 @default.
- W2800650801 cites W2133323723 @default.
- W2800650801 cites W2134230584 @default.
- W2800650801 cites W2134861285 @default.
- W2800650801 cites W2135314242 @default.
- W2800650801 cites W2147318282 @default.
- W2800650801 cites W2150680216 @default.
- W2800650801 cites W2151177887 @default.
- W2800650801 cites W2166601968 @default.
- W2800650801 cites W2168632005 @default.
- W2800650801 cites W2169008732 @default.
- W2800650801 cites W2172242534 @default.
- W2800650801 cites W2192121806 @default.
- W2800650801 cites W2213486556 @default.
- W2800650801 cites W2216772862 @default.
- W2800650801 cites W2233614027 @default.
- W2800650801 cites W2275948481 @default.
- W2800650801 cites W2291176625 @default.
- W2800650801 cites W2318933236 @default.
- W2800650801 cites W2338693134 @default.
- W2800650801 cites W2339774970 @default.
- W2800650801 cites W2369297677 @default.
- W2800650801 cites W2465678433 @default.
- W2800650801 cites W2485824342 @default.
- W2800650801 cites W2511409090 @default.
- W2800650801 cites W2517675534 @default.
- W2800650801 cites W2521204548 @default.
- W2800650801 cites W2529212447 @default.
- W2800650801 cites W2559486183 @default.
- W2800650801 cites W2573476619 @default.
- W2800650801 cites W2582696216 @default.
- W2800650801 cites W2618010906 @default.
- W2800650801 cites W2762535272 @default.
- W2800650801 cites W2979637638 @default.
- W2800650801 cites W4210983280 @default.
- W2800650801 cites W4235838915 @default.
- W2800650801 cites W75709240 @default.
- W2800650801 doi "https://doi.org/10.1007/978-3-319-75184-9_2" @default.
- W2800650801 hasPublicationYear "2018" @default.
- W2800650801 type Work @default.
- W2800650801 sameAs 2800650801 @default.
- W2800650801 citedByCount "0" @default.
- W2800650801 crossrefType "book-chapter" @default.
- W2800650801 hasAuthorship W2800650801A5081326206 @default.
- W2800650801 hasAuthorship W2800650801A5090348753 @default.
- W2800650801 hasAuthorship W2800650801A5090470607 @default.
- W2800650801 hasConcept C114851261 @default.
- W2800650801 hasConcept C126322002 @default.
- W2800650801 hasConcept C142424586 @default.