FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800672823> ?p ?o ?g. }

• W2800672823 endingPage "e0196587" @default.
• W2800672823 startingPage "e0196587" @default.
• W2800672823 abstract "Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders. Recently we have generated Cdkl5 KO mice by targeting exon 2 on the C57BL/6N background, and demonstrated postsynaptic overaccumulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the hippocampus. In the current study, we subjected the Cdkl5 KO mice to a battery of comprehensive behavioral tests, aiming to reveal the effects of loss of CDKL5 in a whole perspective of motor, emotional, social, and cognition/memory functions, and to identify its undetermined roles. The neurological screen, rotarod, hot plate, prepulse inhibition, light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, one-chamber and three-chamber social interaction, 24-h home cage monitoring, contextual and cued fear conditioning, Barnes maze, and T-maze tests were applied on adult Cdkl5 -/Y and +/Y mice. Cdkl5 -/Y mice showed a mild alteration in the gait. Analyses of emotional behaviors revealed significantly enhanced anxiety-like behaviors of Cdkl5 -/Y mice. Depressive-like behaviors and social interaction of Cdkl5 -/Y mice were uniquely altered. The contextual and cued fear conditioning of Cdkl5 -/Y mice were comparable to control mice; however, Cdkl5 -/Y mice showed a significantly increased freezing time and a significantly decreased distance traveled during the pretone period in the altered context. Both acquisition and long-term retention of spatial reference memory were significantly impaired. The morphometric analysis of hippocampal CA1 pyramidal neurons revealed impaired dendritic arborization and immature spine development in Cdkl5 -/Y mice. These results indicate that CDKL5 plays significant roles in regulating emotional behaviors especially on anxiety- and fear-related responses, and in both acquisition and long-term retention of spatial reference memory, which suggests that focus and special attention should be paid to the specific mechanisms of these deficits in the CDKL5 deficiency disorder." @default.
• W2800672823 created "2018-05-17" @default.
• W2800672823 creator A5008391815 @default.
• W2800672823 creator A5035387244 @default.
• W2800672823 creator A5058103958 @default.
• W2800672823 creator A5074027081 @default.
• W2800672823 creator A5082773543 @default.
• W2800672823 creator A5086676643 @default.
• W2800672823 date "2018-04-27" @default.
• W2800672823 modified "2023-10-15" @default.
• W2800672823 title "Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory" @default.
• W2800672823 cites W1254699444 @default.
• W2800672823 cites W1481762643 @default.
• W2800672823 cites W1624178692 @default.
• W2800672823 cites W1876061808 @default.
• W2800672823 cites W1963956528 @default.
• W2800672823 cites W1967531155 @default.
• W2800672823 cites W1967887989 @default.
• W2800672823 cites W1976924995 @default.
• W2800672823 cites W1982568751 @default.
• W2800672823 cites W1984458059 @default.
• W2800672823 cites W1984882298 @default.
• W2800672823 cites W1991169444 @default.
• W2800672823 cites W1999024554 @default.
• W2800672823 cites W2004905652 @default.
• W2800672823 cites W2010947503 @default.
• W2800672823 cites W2011397887 @default.
• W2800672823 cites W2015363601 @default.
• W2800672823 cites W2016725080 @default.
• W2800672823 cites W2018213389 @default.
• W2800672823 cites W2023725147 @default.
• W2800672823 cites W2025669261 @default.
• W2800672823 cites W2032561635 @default.
• W2800672823 cites W2037351588 @default.
• W2800672823 cites W2039348342 @default.
• W2800672823 cites W2041469451 @default.
• W2800672823 cites W2041561931 @default.
• W2800672823 cites W2049021349 @default.
• W2800672823 cites W2049868560 @default.
• W2800672823 cites W2050066016 @default.
• W2800672823 cites W2051718217 @default.
• W2800672823 cites W2054206376 @default.
• W2800672823 cites W2056097987 @default.
• W2800672823 cites W2064981193 @default.
• W2800672823 cites W2065579814 @default.
• W2800672823 cites W2066779634 @default.
• W2800672823 cites W2070058093 @default.
• W2800672823 cites W2072799387 @default.
• W2800672823 cites W2073799411 @default.
• W2800672823 cites W2076018693 @default.
• W2800672823 cites W2080019131 @default.
• W2800672823 cites W2082070355 @default.
• W2800672823 cites W2084522972 @default.
• W2800672823 cites W2084971062 @default.
• W2800672823 cites W2085642655 @default.
• W2800672823 cites W2090470620 @default.
• W2800672823 cites W2100064902 @default.
• W2800672823 cites W2100134781 @default.
• W2800672823 cites W2103661790 @default.
• W2800672823 cites W2104202813 @default.
• W2800672823 cites W2105089471 @default.
• W2800672823 cites W2109091674 @default.
• W2800672823 cites W2109276098 @default.
• W2800672823 cites W2112589391 @default.
• W2800672823 cites W2113299257 @default.
• W2800672823 cites W2127810309 @default.
• W2800672823 cites W2132701025 @default.
• W2800672823 cites W2133558343 @default.
• W2800672823 cites W2135126450 @default.
• W2800672823 cites W2147819824 @default.
• W2800672823 cites W2160360131 @default.
• W2800672823 cites W2168175444 @default.
• W2800672823 cites W2172130553 @default.
• W2800672823 cites W2173711355 @default.
• W2800672823 cites W2260115926 @default.
• W2800672823 cites W2344592563 @default.
• W2800672823 cites W2505355368 @default.
• W2800672823 cites W2558841755 @default.
• W2800672823 cites W2733418771 @default.
• W2800672823 cites W2734147076 @default.
• W2800672823 cites W2734458034 @default.
• W2800672823 cites W2739287754 @default.
• W2800672823 cites W4239233660 @default.
• W2800672823 cites W851044123 @default.
• W2800672823 doi "https://doi.org/10.1371/journal.pone.0196587" @default.
• W2800672823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5922552" @default.
• W2800672823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29702698" @default.
• W2800672823 hasPublicationYear "2018" @default.
• W2800672823 type Work @default.
• W2800672823 sameAs 2800672823 @default.
• W2800672823 citedByCount "50" @default.
• W2800672823 countsByYear W28006728232018 @default.
• W2800672823 countsByYear W28006728232019 @default.
• W2800672823 countsByYear W28006728232020 @default.
• W2800672823 countsByYear W28006728232021 @default.
• W2800672823 countsByYear W28006728232022 @default.
• W2800672823 countsByYear W28006728232023 @default.
• W2800672823 crossrefType "journal-article" @default.

• next