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- W2800680014 abstract "Abstract A number of highly curved membranes in vivo, such as epithelial cell microvilli, have the relatively high sphingolipid content associated with raft-like composition. Given the much lower bending energy measured for bilayers with nonraft low sphingomyelin and low cholesterol content, observing high curvature for presumably more rigid compositions seems counterintuitive. To understand this behavior, we measured membrane rigidity by fluctuation analysis of giant unilamellar vesicles. We found that including a transmembrane helical GWALP peptide increases the membrane bending modulus of the liquid-disordered (Ld) phase. We observed this increase at both low-cholesterol fraction and higher, more physiological cholesterol fraction. We find that simplified, commonly used Ld and liquid-ordered (Lo) phases are not representative of those that coexist. When Ld and Lo phases coexist, GWALP peptide favors the Ld phase with a partition coefficient of 3–10 depending on mixture composition. In model membranes at high cholesterol fractions, Ld phases with GWALP have greater bending moduli than the Lo phase that would coexist." @default.
- W2800680014 created "2018-05-17" @default.
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- W2800680014 date "2018-05-01" @default.
- W2800680014 modified "2023-10-16" @default.
- W2800680014 title "Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide" @default.
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- W2800680014 doi "https://doi.org/10.1016/j.bpj.2018.03.026" @default.
- W2800680014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6035299" @default.
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- W2800680014 hasPublicationYear "2018" @default.
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