Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800683419> ?p ?o ?g. }
- W2800683419 endingPage "2137" @default.
- W2800683419 startingPage "2125" @default.
- W2800683419 abstract "Huntington's disease (HD) is a neurodegenerative disorder causing cognitive and motor impairments, evolving to death within 15-20 years after symptom onset. We previously established a mouse model with the entire human HD gene containing 128 CAG repeats (YAC128) which accurately recapitulates the natural history of the human disease. Defined time points in this natural history enable the understanding of longitudinal trajectories from the neurochemical and structural points of view using non-invasive high-resolution multi-modal imaging. Accordingly, we designed a longitudinal structural imaging (MRI and DTI) and spectroscopy (1H-MRS) study in YAC128, at 3, 6, 9 and 12 months of age, at 9.4 T. Structural analysis (MRI/DTI), confirmed that the striatum is the earliest affected brain region, but other regions were also identified through connectivity analysis (pre-frontal cortex, hippocampus, globus pallidus and thalamus), suggesting a striking homology with the human disease. Importantly, we found for the first time, a negative correlation between striatal and hippocampal changes only in YAC128. In fact, the striatum showed accelerated volumetric decay in HD, as opposed to the hippocampus. Neurochemical analysis of the HD striatum suggested early neurometabolic alterations in neurotransmission and metabolism, with a significant increase in striatal GABA levels, and specifically anticorrelated levels of N-acetyl aspartate and taurine, suggesting that the later is homeostatically adjusted for neuroprotection, as neural loss, indicated by the former, is progressing. These results provide novel insights into the natural history of HD and prove a valuable role for longitudinal multi-modal panels of structural and metabolite/neurotransmission in the YAC128 model." @default.
- W2800683419 created "2018-05-17" @default.
- W2800683419 creator A5012891403 @default.
- W2800683419 creator A5025687810 @default.
- W2800683419 creator A5040546791 @default.
- W2800683419 creator A5043027619 @default.
- W2800683419 creator A5045668678 @default.
- W2800683419 creator A5047722409 @default.
- W2800683419 creator A5054608866 @default.
- W2800683419 creator A5084533263 @default.
- W2800683419 creator A5091005808 @default.
- W2800683419 date "2018-04-16" @default.
- W2800683419 modified "2023-10-14" @default.
- W2800683419 title "A whole brain longitudinal study in the YAC128 mouse model of Huntington’s disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes" @default.
- W2800683419 cites W1274773852 @default.
- W2800683419 cites W1680162993 @default.
- W2800683419 cites W1834161563 @default.
- W2800683419 cites W1966491155 @default.
- W2800683419 cites W1982422745 @default.
- W2800683419 cites W1987448986 @default.
- W2800683419 cites W1995119071 @default.
- W2800683419 cites W1997732141 @default.
- W2800683419 cites W1998316883 @default.
- W2800683419 cites W1998585067 @default.
- W2800683419 cites W2000561294 @default.
- W2800683419 cites W2006952111 @default.
- W2800683419 cites W2015789019 @default.
- W2800683419 cites W2015852090 @default.
- W2800683419 cites W2023887531 @default.
- W2800683419 cites W2034175695 @default.
- W2800683419 cites W2037184235 @default.
- W2800683419 cites W2038979894 @default.
- W2800683419 cites W2041214350 @default.
- W2800683419 cites W2043078214 @default.
- W2800683419 cites W2048599819 @default.
- W2800683419 cites W2073466689 @default.
- W2800683419 cites W2087157508 @default.
- W2800683419 cites W2087820899 @default.
- W2800683419 cites W2092707982 @default.
- W2800683419 cites W2093037844 @default.
- W2800683419 cites W2103628198 @default.
- W2800683419 cites W2105077280 @default.
- W2800683419 cites W2105749284 @default.
- W2800683419 cites W2105807400 @default.
- W2800683419 cites W2110684391 @default.
- W2800683419 cites W2117471869 @default.
- W2800683419 cites W2121642311 @default.
- W2800683419 cites W2124515970 @default.
- W2800683419 cites W2133141500 @default.
- W2800683419 cites W2133243301 @default.
- W2800683419 cites W2145598776 @default.
- W2800683419 cites W2156886710 @default.
- W2800683419 cites W2162532664 @default.
- W2800683419 cites W2163671213 @default.
- W2800683419 cites W2166171037 @default.
- W2800683419 cites W2166305980 @default.
- W2800683419 cites W2170256902 @default.
- W2800683419 cites W2267461392 @default.
- W2800683419 cites W2509688377 @default.
- W2800683419 cites W2518854692 @default.
- W2800683419 cites W4212857193 @default.
- W2800683419 doi "https://doi.org/10.1093/hmg/ddy119" @default.
- W2800683419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29668904" @default.
- W2800683419 hasPublicationYear "2018" @default.
- W2800683419 type Work @default.
- W2800683419 sameAs 2800683419 @default.
- W2800683419 citedByCount "23" @default.
- W2800683419 countsByYear W28006834192018 @default.
- W2800683419 countsByYear W28006834192019 @default.
- W2800683419 countsByYear W28006834192020 @default.
- W2800683419 countsByYear W28006834192021 @default.
- W2800683419 countsByYear W28006834192022 @default.
- W2800683419 countsByYear W28006834192023 @default.
- W2800683419 crossrefType "journal-article" @default.
- W2800683419 hasAuthorship W2800683419A5012891403 @default.
- W2800683419 hasAuthorship W2800683419A5025687810 @default.
- W2800683419 hasAuthorship W2800683419A5040546791 @default.
- W2800683419 hasAuthorship W2800683419A5043027619 @default.
- W2800683419 hasAuthorship W2800683419A5045668678 @default.
- W2800683419 hasAuthorship W2800683419A5047722409 @default.
- W2800683419 hasAuthorship W2800683419A5054608866 @default.
- W2800683419 hasAuthorship W2800683419A5084533263 @default.
- W2800683419 hasAuthorship W2800683419A5091005808 @default.
- W2800683419 hasBestOaLocation W28006834191 @default.
- W2800683419 hasConcept C126322002 @default.
- W2800683419 hasConcept C169760540 @default.
- W2800683419 hasConcept C25876315 @default.
- W2800683419 hasConcept C2777670902 @default.
- W2800683419 hasConcept C2778187257 @default.
- W2800683419 hasConcept C2779134260 @default.
- W2800683419 hasConcept C2779246727 @default.
- W2800683419 hasConcept C2779714222 @default.
- W2800683419 hasConcept C2780062018 @default.
- W2800683419 hasConcept C2780278869 @default.
- W2800683419 hasConcept C2780647506 @default.
- W2800683419 hasConcept C2781161787 @default.
- W2800683419 hasConcept C513476851 @default.
- W2800683419 hasConcept C529278444 @default.