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- W2800690470 abstract "Atopic Dermatitis is a common skin condition that clinically presents as erythematic, dry, pruritic skin. While multiple factors contribute to the pathophysiology of the disease, prominent Th2-mediated immune responses are characteristic of AD. Interleukin-4 (IL-4) and Interleukin-13 may contribute to the pathogenesis of AD. Minipigs are used frequently for toxicity/safety of dermally applied products, and thus a model of AD in minipigs would be beneficial for pre-clinical efficacy tests of such medications. This study assessed sensitivity of Hanford minipigs to recombinant porcine (rp) IL-4 and IL-13. Peripheral Blood Mononuclear Cells (PBMC) isolated from female Hanford minipigs demonstrated approximately a 4 fold increase in STAT6 phosphorylation when challenged with rpIL-4, but not rpIL-13. When female Hanfords received a single intradermal dose of rpIL-4 or rpIL-13, erythema and edema was not different from vehicle control dose sites. However, repeat intradermal injections for a period of five days did elicit increased erythema and edema in rpIL-4 dose sites relative to vehicle control, but not rpIL-13 dose sites. The peak irritation was observed approximately 5 minutes after dose administration, similar to histamine injections in minipigs. Interestingly, perivascular or dermal lymphocytes were observed in ∼25-38% of rpIL-4 and rpIL-13 dose sites, but were not present in the vehicle control sites. Perivascular eosinophils were observed in ∼25% of the rpIL-4 dose sites, while not observed in vehicle or rpIL-13 dose sites. This suggests that intradermal injection of rpIL-4 and rpIL-13 may recruit lymphocytes to dermal tissues. These findings that rpIL-4 and rpIL-13 appear to have biological activity in Hanford minipigs, and are good candidates for further exploration in developing a porcine model of Atopic Dermatitis." @default.
- W2800690470 created "2018-05-17" @default.
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- W2800690470 date "2018-05-01" @default.
- W2800690470 modified "2023-10-18" @default.
- W2800690470 title "1069 Minipig model of atopic dermatitis: Assessment of in vivo and in vitro activity of recombinant porcine interleukin-4 and interleukin-13" @default.
- W2800690470 doi "https://doi.org/10.1016/j.jid.2018.03.1082" @default.
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