Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800691271> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2800691271 endingPage "2234" @default.
- W2800691271 startingPage "2223" @default.
- W2800691271 abstract "Introduction: Asian countries have the highest burden of liver diseases. Polygonum plebeium (P. plebeium), a.k.a. the common knotweed, is a species of plant in the knotwood family that can act as a blood purifier and has been widely used in Pakistan to cure liver disorders like jaundice and hepatitis. The plant is also used in the treatment of pneumonia, bowel complaints, diarrhea, dysentery, eczema and ring worms. Tannins, flavonoids, saponins and alkaloids are the major components of P. plebeium. Since its use in folk medicine in Pakistan, there has been little scientific evidence or information on it. Therefore, this study was aimed at investigating the anti-fibrotic effects of P. plebeium in carbon tetrachloride (CCl4)-induced hepatic toxicity and fibrosis.
 Methods: The extracts of whole plant of P. plebeium were prepared and administered by oral gavage in rats. Liver fibrosis was induced by intraperitoneal (i.p.) administration of CCl4. To evaluate the hepatoprotective activity of P. plebeium, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (γGT) levels were quantified. Histological evaluation of liver tissue revealed tissue necrosis and extracellular matrix deposition. Real-time PCR was done to evaluate mRNA expression of genes related to liver fibrosis.
 Results: The groups treated with P. plebeium extract showed an ablation in liver damage; the elevated enzyme levels of ALT, AST and γGT were decreased. Treatment with P. plebeium extract treatment restored the CCl4-induced tissue fibrosis by significantly suppressing alpha-smooth muscle actin (α-SMA), tumor growth factor beta (TGF-β) and collagen mRNA expression levels. Histology of liver sections also showed that the CCl4-induced fibrosis was improved in the treatment groups.
 Conclusion: Polygonum plebeium has therapeutic potential and can be used for preventing fibrosis in inflammatory liver disease." @default.
- W2800691271 created "2018-05-17" @default.
- W2800691271 creator A5010357573 @default.
- W2800691271 creator A5013457660 @default.
- W2800691271 creator A5022272858 @default.
- W2800691271 creator A5024021715 @default.
- W2800691271 creator A5062957708 @default.
- W2800691271 date "2018-04-29" @default.
- W2800691271 modified "2023-09-24" @default.
- W2800691271 title "Anti-fibrotic effects of polygonum plebeium r.br. in CCl4-induced hepatic damage and fibrosis in rats" @default.
- W2800691271 doi "https://doi.org/10.15419/bmrat.v5i4.435" @default.
- W2800691271 hasPublicationYear "2018" @default.
- W2800691271 type Work @default.
- W2800691271 sameAs 2800691271 @default.
- W2800691271 citedByCount "3" @default.
- W2800691271 countsByYear W28006912712021 @default.
- W2800691271 countsByYear W28006912712022 @default.
- W2800691271 crossrefType "journal-article" @default.
- W2800691271 hasAuthorship W2800691271A5010357573 @default.
- W2800691271 hasAuthorship W2800691271A5013457660 @default.
- W2800691271 hasAuthorship W2800691271A5022272858 @default.
- W2800691271 hasAuthorship W2800691271A5024021715 @default.
- W2800691271 hasAuthorship W2800691271A5062957708 @default.
- W2800691271 hasBestOaLocation W28006912711 @default.
- W2800691271 hasConcept C102124568 @default.
- W2800691271 hasConcept C126322002 @default.
- W2800691271 hasConcept C142724271 @default.
- W2800691271 hasConcept C178790620 @default.
- W2800691271 hasConcept C185592680 @default.
- W2800691271 hasConcept C2776029263 @default.
- W2800691271 hasConcept C2776637226 @default.
- W2800691271 hasConcept C2777359374 @default.
- W2800691271 hasConcept C2778351090 @default.
- W2800691271 hasConcept C2780559512 @default.
- W2800691271 hasConcept C71924100 @default.
- W2800691271 hasConcept C90924648 @default.
- W2800691271 hasConcept C98274493 @default.
- W2800691271 hasConceptScore W2800691271C102124568 @default.
- W2800691271 hasConceptScore W2800691271C126322002 @default.
- W2800691271 hasConceptScore W2800691271C142724271 @default.
- W2800691271 hasConceptScore W2800691271C178790620 @default.
- W2800691271 hasConceptScore W2800691271C185592680 @default.
- W2800691271 hasConceptScore W2800691271C2776029263 @default.
- W2800691271 hasConceptScore W2800691271C2776637226 @default.
- W2800691271 hasConceptScore W2800691271C2777359374 @default.
- W2800691271 hasConceptScore W2800691271C2778351090 @default.
- W2800691271 hasConceptScore W2800691271C2780559512 @default.
- W2800691271 hasConceptScore W2800691271C71924100 @default.
- W2800691271 hasConceptScore W2800691271C90924648 @default.
- W2800691271 hasConceptScore W2800691271C98274493 @default.
- W2800691271 hasIssue "4" @default.
- W2800691271 hasLocation W28006912711 @default.
- W2800691271 hasOpenAccess W2800691271 @default.
- W2800691271 hasPrimaryLocation W28006912711 @default.
- W2800691271 hasRelatedWork W1037510925 @default.
- W2800691271 hasRelatedWork W138459547 @default.
- W2800691271 hasRelatedWork W1887916409 @default.
- W2800691271 hasRelatedWork W1991493628 @default.
- W2800691271 hasRelatedWork W2009144385 @default.
- W2800691271 hasRelatedWork W2013989334 @default.
- W2800691271 hasRelatedWork W2433899263 @default.
- W2800691271 hasRelatedWork W2463619613 @default.
- W2800691271 hasRelatedWork W2770687627 @default.
- W2800691271 hasRelatedWork W994109976 @default.
- W2800691271 hasVolume "5" @default.
- W2800691271 isParatext "false" @default.
- W2800691271 isRetracted "false" @default.
- W2800691271 magId "2800691271" @default.
- W2800691271 workType "article" @default.