Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800693019> ?p ?o ?g. }
- W2800693019 endingPage "292.e5" @default.
- W2800693019 startingPage "292.e1" @default.
- W2800693019 abstract "The ε4 allele of the apolipoprotein E (APOE) gene common polymorphism is the strongest genetic risk factor for Alzheimer's disease (AD). Human APOE gene is located on chromosome 19q13.1, a region linked to AD that also includes the LSR gene, which encodes the lipolysis-stimulated lipoprotein receptor (LSR). As an APOE receptor, LSR is involved in the regulation of lipid homeostasis in both periphery and brain. This study aimed to determine the potential interactions between 2 LSR genetic variants, rs34259399 and rs916147, and the APOE common polymorphism in 142 AD subjects (mean age: 73.16 ± 8.50 years) and 63 controls (mean age: 70.41 ± 8.49 years). A significant epistatic interaction was observed between APOE and both LSR variants, rs34259399 (beta = −0.95; p = 2 × 10−5) and rs916147 (beta = −0.83; p = 6.8 × 10−3). Interestingly, the interaction of LSR polymorphisms with APOE non-ε4 alleles increased AD risk. This indicates the existence of complex molecular interactions between these 2 neighboring genes involved in the pathogenesis of AD, which merits further investigation." @default.
- W2800693019 created "2018-05-17" @default.
- W2800693019 creator A5003656315 @default.
- W2800693019 creator A5005892790 @default.
- W2800693019 creator A5031084437 @default.
- W2800693019 creator A5046388205 @default.
- W2800693019 creator A5064671837 @default.
- W2800693019 creator A5074894204 @default.
- W2800693019 creator A5087079355 @default.
- W2800693019 date "2018-09-01" @default.
- W2800693019 modified "2023-10-14" @default.
- W2800693019 title "Epistatic interaction of apolipoprotein E and lipolysis-stimulated lipoprotein receptor genetic variants is associated with Alzheimer's disease" @default.
- W2800693019 cites W1525254184 @default.
- W2800693019 cites W1957851970 @default.
- W2800693019 cites W1966808578 @default.
- W2800693019 cites W1966895399 @default.
- W2800693019 cites W1978219957 @default.
- W2800693019 cites W1978737597 @default.
- W2800693019 cites W1989259683 @default.
- W2800693019 cites W1990008286 @default.
- W2800693019 cites W1993668532 @default.
- W2800693019 cites W2000223104 @default.
- W2800693019 cites W2004127466 @default.
- W2800693019 cites W2014029619 @default.
- W2800693019 cites W2022323129 @default.
- W2800693019 cites W2026895373 @default.
- W2800693019 cites W2031340288 @default.
- W2800693019 cites W2032212934 @default.
- W2800693019 cites W2036362108 @default.
- W2800693019 cites W2037330433 @default.
- W2800693019 cites W2046335519 @default.
- W2800693019 cites W2049370364 @default.
- W2800693019 cites W2056516296 @default.
- W2800693019 cites W2059664914 @default.
- W2800693019 cites W2060911735 @default.
- W2800693019 cites W2069815951 @default.
- W2800693019 cites W2076615525 @default.
- W2800693019 cites W2077426121 @default.
- W2800693019 cites W2077592857 @default.
- W2800693019 cites W2079517191 @default.
- W2800693019 cites W2085276148 @default.
- W2800693019 cites W2092667917 @default.
- W2800693019 cites W2097112082 @default.
- W2800693019 cites W2102514878 @default.
- W2800693019 cites W2102736631 @default.
- W2800693019 cites W2111774300 @default.
- W2800693019 cites W2117156629 @default.
- W2800693019 cites W2129586493 @default.
- W2800693019 cites W2134458253 @default.
- W2800693019 cites W2143955562 @default.
- W2800693019 cites W2148573574 @default.
- W2800693019 cites W2149486086 @default.
- W2800693019 cites W2151926406 @default.
- W2800693019 cites W2152681705 @default.
- W2800693019 cites W2166213292 @default.
- W2800693019 cites W2560393860 @default.
- W2800693019 cites W2594331538 @default.
- W2800693019 cites W2601738889 @default.
- W2800693019 cites W2603910820 @default.
- W2800693019 cites W3014251530 @default.
- W2800693019 doi "https://doi.org/10.1016/j.neurobiolaging.2018.04.013" @default.
- W2800693019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29858039" @default.
- W2800693019 hasPublicationYear "2018" @default.
- W2800693019 type Work @default.
- W2800693019 sameAs 2800693019 @default.
- W2800693019 citedByCount "4" @default.
- W2800693019 countsByYear W28006930192020 @default.
- W2800693019 countsByYear W28006930192021 @default.
- W2800693019 countsByYear W28006930192022 @default.
- W2800693019 crossrefType "journal-article" @default.
- W2800693019 hasAuthorship W2800693019A5003656315 @default.
- W2800693019 hasAuthorship W2800693019A5005892790 @default.
- W2800693019 hasAuthorship W2800693019A5031084437 @default.
- W2800693019 hasAuthorship W2800693019A5046388205 @default.
- W2800693019 hasAuthorship W2800693019A5064671837 @default.
- W2800693019 hasAuthorship W2800693019A5074894204 @default.
- W2800693019 hasAuthorship W2800693019A5087079355 @default.
- W2800693019 hasConcept C104317684 @default.
- W2800693019 hasConcept C126322002 @default.
- W2800693019 hasConcept C134018914 @default.
- W2800693019 hasConcept C180754005 @default.
- W2800693019 hasConcept C2778163477 @default.
- W2800693019 hasConcept C2779134260 @default.
- W2800693019 hasConcept C2780072125 @default.
- W2800693019 hasConcept C43554185 @default.
- W2800693019 hasConcept C502032728 @default.
- W2800693019 hasConcept C54355233 @default.
- W2800693019 hasConcept C57089818 @default.
- W2800693019 hasConcept C61727976 @default.
- W2800693019 hasConcept C62746215 @default.
- W2800693019 hasConcept C71924100 @default.
- W2800693019 hasConcept C86803240 @default.
- W2800693019 hasConceptScore W2800693019C104317684 @default.
- W2800693019 hasConceptScore W2800693019C126322002 @default.
- W2800693019 hasConceptScore W2800693019C134018914 @default.
- W2800693019 hasConceptScore W2800693019C180754005 @default.
- W2800693019 hasConceptScore W2800693019C2778163477 @default.
- W2800693019 hasConceptScore W2800693019C2779134260 @default.