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- W2800696062 abstract "A series of new 6-styryl-naphthalene-2-amidrazone derivatives were synthesized and evaluated as potential ASIC1a inhibitors. Among them, compound 5e showed the most activity to inhibit [Ca2+]i. elevation in acid-induced articular chondrocytes. Together with the important role of ASIC1a in the pathogenesis of tissue acidification diseases including rheumatoid arthritis, these results might provide a meaningful hint or inspiration in developing drugs targeting at tissue acidification diseases." @default.
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- W2800696062 date "2018-07-01" @default.
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- W2800696062 title "Novel amidrazone derivatives: Design, synthesis and activity evaluation" @default.
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- W2800696062 doi "https://doi.org/10.1016/j.bmc.2018.04.042" @default.
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