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- W2800707914 abstract "This thesis aims to extend the existing knowledge and enhance the methodological quality of future stepped-wedge cluster randomised trial (SW-CRTs). A systematic review of published SW-CRTs shows that pre-trial sample sizes calculations display a poor standard of reporting, with little adherence to published guidelines. The methodological rigor is often substandard, with inappropriate methods often used to determine sample size. In SW-CRTs, it is assumed that the correlation between observations is independent of the timing of them. We test the validity of this assumption by outlining a method to estimate the within-period and inter-period correlation. A case study illustrates what these correlations may look like in practice. The impact of varying cluster size in a SW-CRT is then demonstrated by comparing a design with unequal cluster size to a design with equal cluster size. A simulation study provides evidence that the SW-CRT is affected less, on average, than a P-CRT by varying cluster size. However, the potential power in a SW-CRT with unequal cluster sizes is extremely variable. A practical method for estimated power in a SW-CRT with varying cluster size is then illustrated through a Stata function." @default.
- W2800707914 created "2018-05-17" @default.
- W2800707914 creator A5006615148 @default.
- W2800707914 date "2018-07-01" @default.
- W2800707914 modified "2023-09-23" @default.
- W2800707914 title "Advancing knowledge in stepped-wedge cluster randomised controlled trials" @default.
- W2800707914 hasPublicationYear "2018" @default.
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