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• W2800754051 abstract "Purpose of review The immune system serves a critical role in protecting the host against various pathogens. However, under circumstances, once triggered by the infectious process, it may be detrimental to the host. This may be as a result of nonspecific immune activation or due to a targeted immune response to a specific host antigen. In this opinion piece, we discuss the underlying mechanisms that lead to such an inflammatory or autoimmune syndrome affecting the nervous system. We examine these hypotheses in the context of recent emerging infections to provide mechanistic insight into the clinical manifestations and rationale for immunomodulatory therapy. Recent findings Some pathogens endure longer than previously thought. Persistent infections may continue to drive immune responses resulting in chronic inflammation or development of autoimmune processes, resulting in damage to the nervous system. Patients with genetic susceptibilities in immune regulation may be particularly vulnerable to pathogen driven autoimmune responses. Summary The presence of prolonged pathogens may result in chronic immune stimulations that drives immune-mediated neurologic complications. Understanding the burden and mechanisms of these processes is challenging but important." @default.
• W2800754051 created "2018-05-17" @default.
• W2800754051 creator A5000097172 @default.
• W2800754051 creator A5084785068 @default.
• W2800754051 date "2018-06-01" @default.
• W2800754051 modified "2023-10-02" @default.
• W2800754051 title "Neurological syndromes driven by postinfectious processes or unrecognized persistent infections" @default.
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• W2800754051 doi "https://doi.org/10.1097/wco.0000000000000553" @default.
• W2800754051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29547402" @default.
• W2800754051 hasPublicationYear "2018" @default.
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