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• W2800763575 abstract "PDGFRβ/PDGF-B interaction plays a role in angiogenesis, and is mandatory in wound healing and cancer treatment. It has been reported that the PDGF-B aptamer was able to bind to PDGF-B, thus regulating the angiogenesis. However, the binding interaction between the aptamer and the growth factor, including the binding sites, has not been well investigated. This study applied a molecular dynamics (MD) simulation to investigate the aptamer-growth factor interaction in the presence or absence of a receptor (PDGFRβ). Characterization of the structure of an aptamer-growth factor complex revealed binding sites from each section in the complex. Upon the complex formation, PDGF-B and its aptamer exhibited less flexibility in their molecular movement, as indicated by the minimum values of RMSD, RMSF, loop-to-loop distance, and the summation of PCA eigenvalues. Our study of residue pairwise interaction demonstrated that the binding interaction was mainly contributed by electrostatic interaction between the positively-charged amino acid and the negatively-charged phosphate backbone. The role of the PDGF-B aptamer in PDGFRβ/PDGF-B interaction was also investigated. We demonstrated that the stability of the Apt-PDGF-B complex could prevent the presence of a competitor, of PDGFRβ, interrupting the binding process. Because the aptamer was capable of binding with PDGF-B, and blocking the growth factor from the PDGFRβ, it could down regulate the consequent signaling pathway. We provide evidence that the PDGF-BB aptamer is a promising molecule for regulation of angiogenesis. The MD study provides a molecular understanding to modification of the aptamer binding interaction, which could be used in a number of medical applications." @default.
• W2800763575 created "2018-05-17" @default.
• W2800763575 creator A5041897479 @default.
• W2800763575 creator A5062554861 @default.
• W2800763575 creator A5078076422 @default.
• W2800763575 creator A5058615333 @default.
• W2800763575 date "2018-06-01" @default.
• W2800763575 modified "2023-09-27" @default.
• W2800763575 title "Effect of PDGF-B aptamer on PDGFRβ/PDGF-B interaction: Molecular dynamics study" @default.
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• W2800763575 cites W1967803927 @default.
• W2800763575 cites W1968984443 @default.
• W2800763575 cites W1969046853 @default.
• W2800763575 cites W1975580333 @default.
• W2800763575 cites W1975738348 @default.
• W2800763575 cites W1978498560 @default.
• W2800763575 cites W1979447715 @default.
• W2800763575 cites W1983899755 @default.
• W2800763575 cites W1983920704 @default.
• W2800763575 cites W1995164506 @default.
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• W2800763575 doi "https://doi.org/10.1016/j.jmgm.2018.04.012" @default.
• W2800763575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29738888" @default.
• W2800763575 hasPublicationYear "2018" @default.
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