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• W2800768085 abstract "Resveratryl triglycolate (RTG) is a hybrid compound derived by the esterification of resveratrol with glycolic acid. This compound has been previously shown to inhibit cellular melanin synthesis in vitro. This study aimed to examine the in vivo skin-depigmenting efficacy of RTG in human participants. In total, 22 women aged between 25 and 49 years with Fitzpatrick skin type III or IV were enrolled. Their forearms were exposed to UV to induce artificial pigmentation. The test product containing 0.4% RTG or the control product was applied twice daily for up to 8 weeks after the artificial pigmentation. The participants visited the research centre every 2 weeks and were subjected to skin assessments. Visual assessment of pigmentation degree and instrumental analysis of melanin index, skin lightness (L* value) and skin colour (individual typology angle, ITAo) indicated enhanced depigmentation of the skin in the test group, compared with the control group, in Weeks 6 and 8 (P < 0.05). No adverse skin reactions were observed in any of the participants during the entire test. This study demonstrated the skin-depigmenting effects of RTG in human participants. le resvératryl triglycolate (RTG) est un composé hybride dérivé de l'estérification du resvératrol avec de l'acide glycolique. Ce composé à précédemment montré une inhibition de la synthèse de mélanine cellulaire in vitro. Cette étude visait à examiner l'efficacité du RTG sur la dépigmentation de la peau in vivo chez des participantes humaines. au total, 22 femmes âgées de 25 à 49 ans ayant un phototype de peau III ou IV selon la classification de Fitzpatrick ont été incluses. Leurs avant-bras ont été exposés à des UV afin d'induire une pigmentation artificielle. Le produit testé contenant 0.4% de RTG ou le produit contrôle a été appliqué deux fois par jour pendant une durée maximale de 8 semaines après la pigmentation artificielle. Les participantes se sont rendues au centre de recherche toutes les 2 semaines et ont fait l'objet d’évaluations de la peau. l’évaluation visuelle du degré de pigmentation et l'analyse instrumentale de l'indice de mélanine, la pâleur de la peau (valeur L*) et la couleur de la peau (angle de typologie individuelle, ATI) ont indiqué une amélioration de la dépigmentation de la peau dans le groupe de test, par rapport au groupe témoin, au cours des semaines 6 et 8 (P < 0.05). Aucune réaction cutanée indésirable n'a été observée chez l'ensemble des participantes pendant l'intégralité du test. l’étude a démontré les effets dépigmentants sur la peau du RTG chez des participantes humaines. The authors declare that there is no conflict of interest regarding the publication of this article." @default.
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• W2800768085 date "2018-06-01" @default.
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• W2800768085 title "Human skin-depigmenting effects of resveratryl triglycolate, a hybrid compound of resveratrol and glycolic acid" @default.
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• W2800768085 doi "https://doi.org/10.1111/ics.12458" @default.
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