FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800769338> ?p ?o ?g. }

• W2800769338 abstract "• Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatment, patients develop resistance by mechanisms that include the establishment of an immune suppressive tumour microenvironment. Thus, understanding how metastatic melanoma cells suppress the immune system is vital to develop effective immunotherapies against this disease. In this study, we find that the innate immune cells, macrophages and dendritic cells are suppressed in metastatic melanoma support instead of inhibiting tumour progression. Treatment of mice bearing metastatic melanoma with the Ig-CDR-based peptide C36L1 is able to restore macrophages and dendritic cells’ immunogenic functions and to inhibit metastatic growth in lungs. Mechanistically, we found that C36L1 interferes with the MIF-CD74 tumour-innate immune cells immunosuppressive signalling pathway and thereby restores an effective anti-tumour immune response. C36L1 directly binds to CD74 on macrophages and dendritic cells, disturbing CD74 structural dynamics and inhibiting MIF signalling through CD74. Our findings suggest that interfering with MIF-CD74 immunosuppressive signalling in macrophages and dendritic cells using peptide-based immunotherapy can restore the anti-tumour immune response in metastatic melanoma. Our study provides the rationale for further development of peptide-based therapies to restore the anti-tumour immune response in melanoma." @default.
• W2800769338 created "2018-05-17" @default.
• W2800769338 creator A5010135765 @default.
• W2800769338 creator A5024297597 @default.
• W2800769338 creator A5031571018 @default.
• W2800769338 creator A5041531383 @default.
• W2800769338 creator A5045561296 @default.
• W2800769338 creator A5056700264 @default.
• W2800769338 creator A5056987691 @default.
• W2800769338 creator A5060773968 @default.
• W2800769338 creator A5068768246 @default.
• W2800769338 creator A5069038549 @default.
• W2800769338 creator A5071573571 @default.
• W2800769338 creator A5076259487 @default.
• W2800769338 date "2018-05-23" @default.
• W2800769338 modified "2023-10-14" @default.
• W2800769338 title "Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma" @default.
• W2800769338 cites W1485720010 @default.
• W2800769338 cites W1601681275 @default.
• W2800769338 cites W1689372518 @default.
• W2800769338 cites W1779367761 @default.
• W2800769338 cites W1893818399 @default.
• W2800769338 cites W1950829641 @default.
• W2800769338 cites W1960665172 @default.
• W2800769338 cites W1963536257 @default.
• W2800769338 cites W1964366119 @default.
• W2800769338 cites W1970431511 @default.
• W2800769338 cites W1971750711 @default.
• W2800769338 cites W1981438811 @default.
• W2800769338 cites W1992465894 @default.
• W2800769338 cites W1994993231 @default.
• W2800769338 cites W2001737701 @default.
• W2800769338 cites W2006804893 @default.
• W2800769338 cites W2010291063 @default.
• W2800769338 cites W2012706912 @default.
• W2800769338 cites W2020795276 @default.
• W2800769338 cites W2029665800 @default.
• W2800769338 cites W2029725208 @default.
• W2800769338 cites W2031286097 @default.
• W2800769338 cites W2033278321 @default.
• W2800769338 cites W2038545166 @default.
• W2800769338 cites W2050216284 @default.
• W2800769338 cites W2054140923 @default.
• W2800769338 cites W2054205127 @default.
• W2800769338 cites W2055521977 @default.
• W2800769338 cites W2060163534 @default.
• W2800769338 cites W2063264144 @default.
• W2800769338 cites W2068046103 @default.
• W2800769338 cites W2073214182 @default.
• W2800769338 cites W2082828965 @default.
• W2800769338 cites W2102958900 @default.
• W2800769338 cites W2103004412 @default.
• W2800769338 cites W2103506867 @default.
• W2800769338 cites W2104584195 @default.
• W2800769338 cites W2112795579 @default.
• W2800769338 cites W2128707728 @default.
• W2800769338 cites W2131581428 @default.
• W2800769338 cites W2132867241 @default.
• W2800769338 cites W2142394051 @default.
• W2800769338 cites W2142483487 @default.
• W2800769338 cites W2143772132 @default.
• W2800769338 cites W2146133435 @default.
• W2800769338 cites W2164281389 @default.
• W2800769338 cites W2165106728 @default.
• W2800769338 cites W2165838507 @default.
• W2800769338 cites W2166569661 @default.
• W2800769338 cites W2181078066 @default.
• W2800769338 cites W2231929816 @default.
• W2800769338 cites W2263019430 @default.
• W2800769338 cites W2320640765 @default.
• W2800769338 cites W2336583997 @default.
• W2800769338 cites W2346614284 @default.
• W2800769338 cites W2395127811 @default.
• W2800769338 cites W2437166935 @default.
• W2800769338 cites W2530909341 @default.
• W2800769338 cites W2535655946 @default.
• W2800769338 cites W2552406608 @default.
• W2800769338 cites W2556339587 @default.
• W2800769338 cites W2589939875 @default.
• W2800769338 cites W2605166062 @default.
• W2800769338 cites W2605233023 @default.
• W2800769338 cites W2760003250 @default.
• W2800769338 cites W2775030564 @default.
• W2800769338 cites W2953036362 @default.
• W2800769338 cites W4210992847 @default.
• W2800769338 cites W4239288354 @default.
• W2800769338 doi "https://doi.org/10.3389/fimmu.2018.01132" @default.
• W2800769338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5974174" @default.
• W2800769338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29875777" @default.
• W2800769338 hasPublicationYear "2018" @default.
• W2800769338 type Work @default.
• W2800769338 sameAs 2800769338 @default.
• W2800769338 citedByCount "84" @default.
• W2800769338 countsByYear W28007693382019 @default.
• W2800769338 countsByYear W28007693382020 @default.
• W2800769338 countsByYear W28007693382021 @default.
• W2800769338 countsByYear W28007693382022 @default.
• W2800769338 countsByYear W28007693382023 @default.
• W2800769338 crossrefType "journal-article" @default.
• W2800769338 hasAuthorship W2800769338A5010135765 @default.

• next