FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800781184> ?p ?o ?g. }

• W2800781184 endingPage "1075" @default.
• W2800781184 startingPage "1069" @default.
• W2800781184 abstract "Abstract A number of polyphenolic compounds present in fruits and vegetables have the capacity to modulate immune responses; however, the impact of the common plant‐derived flavonoid myricetin on T lymphocyte function has not been investigated. We show that myricetin inhibited mouse T lymphocyte activation by bead‐immobilized anti‐CD3 and anti‐CD28 monoclonal antibodies, as indicated by a dose‐dependent reduction in cell proliferation and decreased synthesis of interferon‐γ, interleukin (IL)‐2, IL‐4, and IL‐17 associated with different T helper cell subsets. This effect was attributed to myricetin‐induced reactive oxygen species (ROS) since myricetin caused hydrogen peroxide (H 2 O 2 ) to accumulate in cell‐free culture medium and H 2 O 2 inhibited T cell proliferation and cytokine synthesis. In addition, the antioxidant N‐acetyl cysteine restored the ability of myricetin‐treated T lymphocytes to proliferate in response to a mitogenic stimulus. The presence of dendritic cells or bone marrow‐derived macrophages negated the inhibitory effect of myricetin on T cell activation, and H 2 O 2 in T cell cultures that were treated with exogenous H 2 O 2 was reduced when antigen‐presenting cells were also present. These findings suggest that antioxidant molecules produced by dendritic cells and macrophages protected T cells from myricetin‐induced oxidative stress, and underscore the importance of considering immune cell interactions when evaluating the immunomodulatory activity of ROS‐generating phytochemicals." @default.
• W2800781184 created "2018-05-17" @default.
• W2800781184 creator A5014068331 @default.
• W2800781184 creator A5054931979 @default.
• W2800781184 creator A5057892911 @default.
• W2800781184 creator A5075092238 @default.
• W2800781184 date "2018-05-10" @default.
• W2800781184 modified "2023-10-01" @default.
• W2800781184 title "Myricetin-induced oxidative stress suppresses murine T lymphocyte activation" @default.
• W2800781184 cites W1535842809 @default.
• W2800781184 cites W1594808249 @default.
• W2800781184 cites W1964046231 @default.
• W2800781184 cites W1966719113 @default.
• W2800781184 cites W1983153802 @default.
• W2800781184 cites W1997215097 @default.
• W2800781184 cites W2013557200 @default.
• W2800781184 cites W2015979406 @default.
• W2800781184 cites W2017853502 @default.
• W2800781184 cites W2023235821 @default.
• W2800781184 cites W2024188254 @default.
• W2800781184 cites W2030470516 @default.
• W2800781184 cites W2034004577 @default.
• W2800781184 cites W2060292237 @default.
• W2800781184 cites W2074047059 @default.
• W2800781184 cites W2083054031 @default.
• W2800781184 cites W2089509570 @default.
• W2800781184 cites W210352952 @default.
• W2800781184 cites W2118278569 @default.
• W2800781184 cites W2126298211 @default.
• W2800781184 cites W2133839289 @default.
• W2800781184 cites W2139644179 @default.
• W2800781184 cites W2152014155 @default.
• W2800781184 cites W2767245839 @default.
• W2800781184 doi "https://doi.org/10.1002/cbin.10977" @default.
• W2800781184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29745443" @default.
• W2800781184 hasPublicationYear "2018" @default.
• W2800781184 type Work @default.
• W2800781184 sameAs 2800781184 @default.
• W2800781184 citedByCount "14" @default.
• W2800781184 countsByYear W28007811842018 @default.
• W2800781184 countsByYear W28007811842019 @default.
• W2800781184 countsByYear W28007811842020 @default.
• W2800781184 countsByYear W28007811842021 @default.
• W2800781184 countsByYear W28007811842022 @default.
• W2800781184 countsByYear W28007811842023 @default.
• W2800781184 crossrefType "journal-article" @default.
• W2800781184 hasAuthorship W2800781184A5014068331 @default.
• W2800781184 hasAuthorship W2800781184A5054931979 @default.
• W2800781184 hasAuthorship W2800781184A5057892911 @default.
• W2800781184 hasAuthorship W2800781184A5075092238 @default.
• W2800781184 hasConcept C153911025 @default.
• W2800781184 hasConcept C154317977 @default.
• W2800781184 hasConcept C185592680 @default.
• W2800781184 hasConcept C202751555 @default.
• W2800781184 hasConcept C203014093 @default.
• W2800781184 hasConcept C2776090121 @default.
• W2800781184 hasConcept C2776151105 @default.
• W2800781184 hasConcept C2777810353 @default.
• W2800781184 hasConcept C2778004101 @default.
• W2800781184 hasConcept C2778173338 @default.
• W2800781184 hasConcept C2779054382 @default.
• W2800781184 hasConcept C48349386 @default.
• W2800781184 hasConcept C55493867 @default.
• W2800781184 hasConcept C67662055 @default.
• W2800781184 hasConcept C86803240 @default.
• W2800781184 hasConcept C8891405 @default.
• W2800781184 hasConcept C95444343 @default.
• W2800781184 hasConceptScore W2800781184C153911025 @default.
• W2800781184 hasConceptScore W2800781184C154317977 @default.
• W2800781184 hasConceptScore W2800781184C185592680 @default.
• W2800781184 hasConceptScore W2800781184C202751555 @default.
• W2800781184 hasConceptScore W2800781184C203014093 @default.
• W2800781184 hasConceptScore W2800781184C2776090121 @default.
• W2800781184 hasConceptScore W2800781184C2776151105 @default.
• W2800781184 hasConceptScore W2800781184C2777810353 @default.
• W2800781184 hasConceptScore W2800781184C2778004101 @default.
• W2800781184 hasConceptScore W2800781184C2778173338 @default.
• W2800781184 hasConceptScore W2800781184C2779054382 @default.
• W2800781184 hasConceptScore W2800781184C48349386 @default.
• W2800781184 hasConceptScore W2800781184C55493867 @default.
• W2800781184 hasConceptScore W2800781184C67662055 @default.
• W2800781184 hasConceptScore W2800781184C86803240 @default.
• W2800781184 hasConceptScore W2800781184C8891405 @default.
• W2800781184 hasConceptScore W2800781184C95444343 @default.
• W2800781184 hasFunder F4320334593 @default.
• W2800781184 hasIssue "8" @default.
• W2800781184 hasLocation W28007811841 @default.
• W2800781184 hasLocation W28007811842 @default.
• W2800781184 hasOpenAccess W2800781184 @default.
• W2800781184 hasPrimaryLocation W28007811841 @default.
• W2800781184 hasRelatedWork W1490540217 @default.
• W2800781184 hasRelatedWork W1667906032 @default.
• W2800781184 hasRelatedWork W2184915799 @default.
• W2800781184 hasRelatedWork W2313463101 @default.
• W2800781184 hasRelatedWork W2368772701 @default.
• W2800781184 hasRelatedWork W2395941482 @default.
• W2800781184 hasRelatedWork W2791181644 @default.
• W2800781184 hasRelatedWork W3197540311 @default.

• next