FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800787815> ?p ?o ?g. }

• W2800787815 endingPage "566" @default.
• W2800787815 startingPage "559" @default.
• W2800787815 abstract "Dermatological diseases, including most skin cancers and rare genetic conditions frequently originate in the epidermis. Targeted, topical cell-based therapy is a promising therapeutic strategy. Here, we present the first report demonstrating that fractional laser ablation enables local 'needle-free' intraepidermal delivery of living human cells.The cells penetrated porcine ear skin via microchannels created by Er:YAG fractional laser ablation; cell delivery was quantified using a haemocytometer. Cutaneous distribution was confirmed visually by laser scanning confocal microscopy and histological analysis.Total cell delivery (sum of amounts permeated and deposited) after 24 h increased from 5.7 ± 0.1 x105 to 9.6 ± 1.6 x105 cells/cm2 when increasing pore density from 300 to 600 pores/cm2, - corresponding to 19- and 32-fold increases over the control. At 600 pores/cm2, cell deposition was 136-fold greater than cell permeation - the latter most likely due to transport from micropores into appendageal pathways. Production of GFP post-delivery confirmed cell remained viability.The results demonstrate the feasibility of using controlled laser microporation to achieve local 'needle-free' cutaneous delivery of living human cells to the epidermis and dermis. This raises the possibility of using this technique for targeted new approaches for dermatological therapy in these regions." @default.
• W2800787815 created "2018-05-17" @default.
• W2800787815 creator A5007160480 @default.
• W2800787815 creator A5048394953 @default.
• W2800787815 creator A5075835563 @default.
• W2800787815 date "2018-05-23" @default.
• W2800787815 modified "2023-10-07" @default.
• W2800787815 title "Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation" @default.
• W2800787815 cites W1568007316 @default.
• W2800787815 cites W1594596002 @default.
• W2800787815 cites W1606835072 @default.
• W2800787815 cites W1964509585 @default.
• W2800787815 cites W1969832444 @default.
• W2800787815 cites W1971277965 @default.
• W2800787815 cites W1973645528 @default.
• W2800787815 cites W1992193183 @default.
• W2800787815 cites W1999670686 @default.
• W2800787815 cites W2000574141 @default.
• W2800787815 cites W2008323089 @default.
• W2800787815 cites W2015934931 @default.
• W2800787815 cites W2018188453 @default.
• W2800787815 cites W2023231194 @default.
• W2800787815 cites W2023686969 @default.
• W2800787815 cites W2029430860 @default.
• W2800787815 cites W2035420641 @default.
• W2800787815 cites W2064067735 @default.
• W2800787815 cites W2064596041 @default.
• W2800787815 cites W2066374070 @default.
• W2800787815 cites W2068962163 @default.
• W2800787815 cites W2084789163 @default.
• W2800787815 cites W2086014349 @default.
• W2800787815 cites W2098214526 @default.
• W2800787815 cites W2115453935 @default.
• W2800787815 cites W2121060467 @default.
• W2800787815 cites W2125297981 @default.
• W2800787815 cites W2125850853 @default.
• W2800787815 cites W2131566159 @default.
• W2800787815 cites W2138437964 @default.
• W2800787815 cites W2141112460 @default.
• W2800787815 cites W2152312983 @default.
• W2800787815 cites W2157916202 @default.
• W2800787815 cites W2169459855 @default.
• W2800787815 cites W2172083530 @default.
• W2800787815 cites W2245075199 @default.
• W2800787815 cites W2278262184 @default.
• W2800787815 cites W2412872453 @default.
• W2800787815 cites W4211003831 @default.
• W2800787815 doi "https://doi.org/10.1080/17425247.2018.1472570" @default.
• W2800787815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29737215" @default.
• W2800787815 hasPublicationYear "2018" @default.
• W2800787815 type Work @default.
• W2800787815 sameAs 2800787815 @default.
• W2800787815 citedByCount "15" @default.
• W2800787815 countsByYear W28007878152019 @default.
• W2800787815 countsByYear W28007878152020 @default.
• W2800787815 countsByYear W28007878152021 @default.
• W2800787815 countsByYear W28007878152022 @default.
• W2800787815 crossrefType "journal-article" @default.
• W2800787815 hasAuthorship W2800787815A5007160480 @default.
• W2800787815 hasAuthorship W2800787815A5048394953 @default.
• W2800787815 hasAuthorship W2800787815A5075835563 @default.
• W2800787815 hasConcept C105702510 @default.
• W2800787815 hasConcept C120665830 @default.
• W2800787815 hasConcept C121332964 @default.
• W2800787815 hasConcept C12554922 @default.
• W2800787815 hasConcept C126322002 @default.
• W2800787815 hasConcept C136229726 @default.
• W2800787815 hasConcept C142724271 @default.
• W2800787815 hasConcept C1491633281 @default.
• W2800787815 hasConcept C185592680 @default.
• W2800787815 hasConcept C192562407 @default.
• W2800787815 hasConcept C2776458125 @default.
• W2800787815 hasConcept C2777459323 @default.
• W2800787815 hasConcept C2777624698 @default.
• W2800787815 hasConcept C2778902805 @default.
• W2800787815 hasConcept C2779178360 @default.
• W2800787815 hasConcept C2779188808 @default.
• W2800787815 hasConcept C520434653 @default.
• W2800787815 hasConcept C54355233 @default.
• W2800787815 hasConcept C55493867 @default.
• W2800787815 hasConcept C71924100 @default.
• W2800787815 hasConcept C86803240 @default.
• W2800787815 hasConcept C95444343 @default.
• W2800787815 hasConceptScore W2800787815C105702510 @default.
• W2800787815 hasConceptScore W2800787815C120665830 @default.
• W2800787815 hasConceptScore W2800787815C121332964 @default.
• W2800787815 hasConceptScore W2800787815C12554922 @default.
• W2800787815 hasConceptScore W2800787815C126322002 @default.
• W2800787815 hasConceptScore W2800787815C136229726 @default.
• W2800787815 hasConceptScore W2800787815C142724271 @default.
• W2800787815 hasConceptScore W2800787815C1491633281 @default.
• W2800787815 hasConceptScore W2800787815C185592680 @default.
• W2800787815 hasConceptScore W2800787815C192562407 @default.
• W2800787815 hasConceptScore W2800787815C2776458125 @default.
• W2800787815 hasConceptScore W2800787815C2777459323 @default.
• W2800787815 hasConceptScore W2800787815C2777624698 @default.
• W2800787815 hasConceptScore W2800787815C2778902805 @default.
• W2800787815 hasConceptScore W2800787815C2779178360 @default.

• next