FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800791350> ?p ?o ?g. }

• W2800791350 abstract "Non-small cell lung carcinoma (NSCLC) is a major subtype of lung cancer. Aberrant DNA methylation has been frequently observed in NSCLC. The aim of the present study was to investigate the role of MyoD family inhibitor (MDFI) methylation in NSCLC. Formalin-fixed paraffin-embedded tumor tissues and adjacent non-cancerous tissues were collected from a total of 111 patients with NSCLC. A methylation assay was performed using the quantitative methylation-specific polymerase chain reaction method. The percentage of methylated reference was used to represent the methylation level of the MDFI promoter. Data mining of a dataset from The Cancer Genome Atlas (TCGA) demonstrated that MDFI promoter methylation levels were significantly increased in 830 tumor tissues compared with 75 non-tumor tissues (P=0.012). However, the results on tissues obtained in the present study indicated that the MDFI promoter methylation levels in tumor tissues were not significantly different compared with those in the adjacent non-tumor tissues (P=0.159). Subsequent breakdown analysis identified that higher MDFI promoter methylation levels were significantly associated with NSCLC in females (P=0.031), but not in males (P=0.832). Age-based subgroup analysis demonstrated that higher MDFI promoter methylation levels were significantly associated with NSCLC in younger patients (≤65 years; P=0.003), but not in older patients (P=0.327). In addition, the association of MDFI methylation with NSCLC was significant in non-smokers (P=0.014), but not in smokers (P=0.832). Similar results also have been determined from subgroup analysis of the TCGA datasets. The Gene Expression Omnibus database indicated MDFI expression restoration in partial lung cancer cell lines (H1299 and Hotz) following demethylation treatment. However, it was identified that MDFI promoter hypermethylation was not significantly associated with prognosis of NSCLC (P>0.05). In conclusion, the present study indicated that the association of higher methylation of the MDFI promoter with NSCLC may be specific to females, non-smokers and people aged ≤65." @default.
• W2800791350 created "2018-05-17" @default.
• W2800791350 creator A5004031758 @default.
• W2800791350 creator A5005211285 @default.
• W2800791350 creator A5015696308 @default.
• W2800791350 creator A5021249077 @default.
• W2800791350 creator A5029695887 @default.
• W2800791350 creator A5075321325 @default.
• W2800791350 creator A5075517974 @default.
• W2800791350 creator A5080247479 @default.
• W2800791350 creator A5091873057 @default.
• W2800791350 date "2018-04-18" @default.
• W2800791350 modified "2023-10-18" @default.
• W2800791350 title "Hypermethylation of MDFI promoter with NSCLC is specific for females, non‑smokers and people younger than 65" @default.
• W2800791350 cites W1525117983 @default.
• W2800791350 cites W1559069178 @default.
• W2800791350 cites W1570858791 @default.
• W2800791350 cites W1675596428 @default.
• W2800791350 cites W1966469380 @default.
• W2800791350 cites W1972452918 @default.
• W2800791350 cites W1977873692 @default.
• W2800791350 cites W1978284325 @default.
• W2800791350 cites W1981296878 @default.
• W2800791350 cites W1981407851 @default.
• W2800791350 cites W1983543579 @default.
• W2800791350 cites W1985213644 @default.
• W2800791350 cites W1996739078 @default.
• W2800791350 cites W1996968784 @default.
• W2800791350 cites W2004172747 @default.
• W2800791350 cites W2010827483 @default.
• W2800791350 cites W2012778694 @default.
• W2800791350 cites W2017214085 @default.
• W2800791350 cites W2019507988 @default.
• W2800791350 cites W2029658031 @default.
• W2800791350 cites W2033445993 @default.
• W2800791350 cites W2034899078 @default.
• W2800791350 cites W2039669402 @default.
• W2800791350 cites W2072694564 @default.
• W2800791350 cites W2079872885 @default.
• W2800791350 cites W2084102070 @default.
• W2800791350 cites W2088159029 @default.
• W2800791350 cites W2103067815 @default.
• W2800791350 cites W211569276 @default.
• W2800791350 cites W2117611226 @default.
• W2800791350 cites W2133700934 @default.
• W2800791350 cites W2140394554 @default.
• W2800791350 cites W2168880641 @default.
• W2800791350 cites W2191560342 @default.
• W2800791350 cites W2284650234 @default.
• W2800791350 cites W2329726206 @default.
• W2800791350 cites W2342551435 @default.
• W2800791350 cites W2460489846 @default.
• W2800791350 cites W2470449457 @default.
• W2800791350 cites W2502786179 @default.
• W2800791350 cites W2511113893 @default.
• W2800791350 cites W2520715551 @default.
• W2800791350 cites W2522815735 @default.
• W2800791350 cites W2547366125 @default.
• W2800791350 cites W2562535631 @default.
• W2800791350 cites W2593670897 @default.
• W2800791350 cites W2597872842 @default.
• W2800791350 cites W341769950 @default.
• W2800791350 cites W4211260867 @default.
• W2800791350 cites W1828505070 @default.
• W2800791350 doi "https://doi.org/10.3892/ol.2018.8535" @default.
• W2800791350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5958687" @default.
• W2800791350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29805634" @default.
• W2800791350 hasPublicationYear "2018" @default.
• W2800791350 type Work @default.
• W2800791350 sameAs 2800791350 @default.
• W2800791350 citedByCount "4" @default.
• W2800791350 countsByYear W28007913502020 @default.
• W2800791350 countsByYear W28007913502022 @default.
• W2800791350 crossrefType "journal-article" @default.
• W2800791350 hasAuthorship W2800791350A5004031758 @default.
• W2800791350 hasAuthorship W2800791350A5005211285 @default.
• W2800791350 hasAuthorship W2800791350A5015696308 @default.
• W2800791350 hasAuthorship W2800791350A5021249077 @default.
• W2800791350 hasAuthorship W2800791350A5029695887 @default.
• W2800791350 hasAuthorship W2800791350A5075321325 @default.
• W2800791350 hasAuthorship W2800791350A5075517974 @default.
• W2800791350 hasAuthorship W2800791350A5080247479 @default.
• W2800791350 hasAuthorship W2800791350A5091873057 @default.
• W2800791350 hasBestOaLocation W28007913501 @default.
• W2800791350 hasConcept C101762097 @default.
• W2800791350 hasConcept C104317684 @default.
• W2800791350 hasConcept C121608353 @default.
• W2800791350 hasConcept C126322002 @default.
• W2800791350 hasConcept C143998085 @default.
• W2800791350 hasConcept C150194340 @default.
• W2800791350 hasConcept C190727270 @default.
• W2800791350 hasConcept C2776256026 @default.
• W2800791350 hasConcept C2777546739 @default.
• W2800791350 hasConcept C2781018059 @default.
• W2800791350 hasConcept C29537977 @default.
• W2800791350 hasConcept C33288867 @default.
• W2800791350 hasConcept C502942594 @default.
• W2800791350 hasConcept C54355233 @default.
• W2800791350 hasConcept C67082663 @default.
• W2800791350 hasConcept C71924100 @default.

• next