Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800843583> ?p ?o ?g. }
- W2800843583 abstract "Calcium (Ca) channels are necessary for cardiac excitation-contraction (e-c) coupling, but Ca channel composition of fish hearts is still largely unknown. To this end, we determined transcript expression of Ca channels in the heart of zebrafish (Danio rerio), a popular model species. Altogether 18 Ca channel α-subunit genes were expressed in both atrium and ventricle. Transcripts for 7 L-type (Cav1.1a, Cav1.1b, Cav1.2, Cav1.3a, Cav1.3b, Cav1.4a, Cav1.4b), 5 T-type (Cav3.1, Cav3.2a, Cav3.2b, Cav3.3a, Cav3.3b) and 6 P/Q-, N- and R-type Ca channels (Cav2.1a, Cav2.1b, Cav2.2a, Cav2.2b, Cav2.3a, Cav2.3b) were expressed. In the ventricle, T-type channels formed 54.9%, L-type channels 41.1% and P/Q-, N- and R-type Ca channels 4.0% of the Ca channel transcripts. In the atrium, the relative expression of T-type and L-type Ca channel transcripts was 64.1% and 33.8%, respectively (others accounted for 2.1%). Thus, at the transcript level T-type Ca channels are prevalent in zebrafish atrium and ventricle. At the functional level, peak densities of ventricular T-type (ICaT) and L-type (ICaL) Ca current were 6.3±0.8 and 7.7±0.8 pA pF−1, respectively. ICaT mediated a sizeable sarcolemmal Ca influx into ventricular myocyte: increment in total cellular Ca content via ICaT was 41.2±7.3 µmol L−1, which was 31.7% of the combined Ca influx (129 µmol L−1) via ICaT and ICaL (88.5±20.5 µmol L−1). The diversity of expressed Ca channel genes in zebrafish heart is high, but dominated by the members of the T-type subfamily. The large ventricular ICaT is likely to play a significant role in e-c coupling." @default.
- W2800843583 created "2018-05-17" @default.
- W2800843583 creator A5002901858 @default.
- W2800843583 creator A5049664557 @default.
- W2800843583 creator A5062989015 @default.
- W2800843583 creator A5075273529 @default.
- W2800843583 date "2018-01-01" @default.
- W2800843583 modified "2023-10-01" @default.
- W2800843583 title "Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels" @default.
- W2800843583 cites W1615535881 @default.
- W2800843583 cites W1899877571 @default.
- W2800843583 cites W1903925553 @default.
- W2800843583 cites W1921440755 @default.
- W2800843583 cites W1967194868 @default.
- W2800843583 cites W1975903898 @default.
- W2800843583 cites W1979013866 @default.
- W2800843583 cites W1982871296 @default.
- W2800843583 cites W1983128983 @default.
- W2800843583 cites W1987416588 @default.
- W2800843583 cites W1996518688 @default.
- W2800843583 cites W2000202306 @default.
- W2800843583 cites W2006424018 @default.
- W2800843583 cites W2007294720 @default.
- W2800843583 cites W2007388823 @default.
- W2800843583 cites W2014808188 @default.
- W2800843583 cites W2014933196 @default.
- W2800843583 cites W2024423290 @default.
- W2800843583 cites W2028736390 @default.
- W2800843583 cites W2039905947 @default.
- W2800843583 cites W2041360032 @default.
- W2800843583 cites W2044362463 @default.
- W2800843583 cites W2046222030 @default.
- W2800843583 cites W2048422633 @default.
- W2800843583 cites W2048671549 @default.
- W2800843583 cites W2048922444 @default.
- W2800843583 cites W2050824263 @default.
- W2800843583 cites W2055571680 @default.
- W2800843583 cites W2059727346 @default.
- W2800843583 cites W2060543464 @default.
- W2800843583 cites W2082470387 @default.
- W2800843583 cites W2084650980 @default.
- W2800843583 cites W2084874490 @default.
- W2800843583 cites W2089238497 @default.
- W2800843583 cites W2089740456 @default.
- W2800843583 cites W2093006233 @default.
- W2800843583 cites W2097256101 @default.
- W2800843583 cites W2098957812 @default.
- W2800843583 cites W2100078256 @default.
- W2800843583 cites W2100579413 @default.
- W2800843583 cites W2101822309 @default.
- W2800843583 cites W2103809282 @default.
- W2800843583 cites W2111814811 @default.
- W2800843583 cites W2117468881 @default.
- W2800843583 cites W2125411585 @default.
- W2800843583 cites W2125505135 @default.
- W2800843583 cites W2133768972 @default.
- W2800843583 cites W2134064208 @default.
- W2800843583 cites W2138151365 @default.
- W2800843583 cites W2143758289 @default.
- W2800843583 cites W2146742484 @default.
- W2800843583 cites W2147383559 @default.
- W2800843583 cites W2148211432 @default.
- W2800843583 cites W2148989249 @default.
- W2800843583 cites W2150589499 @default.
- W2800843583 cites W2157847511 @default.
- W2800843583 cites W2163016631 @default.
- W2800843583 cites W2163135534 @default.
- W2800843583 cites W2165727470 @default.
- W2800843583 cites W2165783384 @default.
- W2800843583 cites W2168394682 @default.
- W2800843583 cites W2168897337 @default.
- W2800843583 cites W2169604515 @default.
- W2800843583 cites W2171830917 @default.
- W2800843583 cites W2215857688 @default.
- W2800843583 cites W2221569376 @default.
- W2800843583 cites W2226437153 @default.
- W2800843583 cites W2277316067 @default.
- W2800843583 cites W2287791542 @default.
- W2800843583 cites W2315780091 @default.
- W2800843583 cites W2415670168 @default.
- W2800843583 cites W2467388958 @default.
- W2800843583 cites W2475906535 @default.
- W2800843583 cites W2741569446 @default.
- W2800843583 cites W2748778076 @default.
- W2800843583 cites W2912991414 @default.
- W2800843583 cites W4235960403 @default.
- W2800843583 cites W4246665087 @default.
- W2800843583 doi "https://doi.org/10.1242/jeb.179226" @default.
- W2800843583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29739832" @default.
- W2800843583 hasPublicationYear "2018" @default.
- W2800843583 type Work @default.
- W2800843583 sameAs 2800843583 @default.
- W2800843583 citedByCount "20" @default.
- W2800843583 countsByYear W28008435832018 @default.
- W2800843583 countsByYear W28008435832019 @default.
- W2800843583 countsByYear W28008435832020 @default.
- W2800843583 countsByYear W28008435832021 @default.
- W2800843583 countsByYear W28008435832022 @default.
- W2800843583 countsByYear W28008435832023 @default.
- W2800843583 crossrefType "journal-article" @default.